Low-Intensity Resistance Training Combined With Blood Flow Restriction and Electrical Stimulation to Improve Leg Function in Stroke Survivors

What this Trial Is About

Researchers are evaluating whether combining low-intensity resistance training with blood flow restriction LIRT-BFR and transcutaneous electrical nerve stimulation TENS can help improve leg function in people who have had a stroke. This study focuses on chronic stroke survivors who often experience lasting leg impairments that affect their mobility and quality of life. The trial is a randomized controlled study aiming to see if this combined approach can restore lower limb strength, mobility, and overall quality of life. Participants will be randomly assigned to one of four groups receiving different combinations of actual or simulated blood flow restriction and electrical nerve stimulation, along with low-intensity resistance training. Each session lasts 60 minutes and includes a warm-up, 40 minutes of exercises like leg extensions, leg presses, and squats targeting the affected leg, followed by stationary cycling. Sessions occur three times per week for six weeks. The blood flow restriction uses an automated cuff placed on the upper leg, inflated during exercises and deflated during rest, while TENS delivers controlled electrical impulses to the anterior thigh. Participants will be assessed before the study, at the halfway point 3 weeks, after completing the intervention 6 weeks, and one month later. Researchers will measure leg motor function using the Fugl-Meyer Assessment for Lower Extremity, plus muscle strength, stiffness, balance, walking ability, and gait. Additional evaluations include muscle oxygen levels, muscle structure by ultrasound, heart rate variability, and perceived exertion to monitor safety. This comprehensive monitoring helps understand how the treatments work and their impact on recovery.

Blood Flow Restriction and Transcutaneous Electrical Nerve Stimulation on Motor Function in Stroke