Low-Intensity Muscle Strengthening with Blood Flow Restriction for Upper Limb Function in People with Multiple Sclerosis A Randomized Controlled Trial

What this Trial Is About

Researchers are evaluating the effects of a low-intensity muscle strengthening program combined with Blood Flow Restriction Training BFRT on upper limb strength, muscle fatigue, coordination, dexterity, functionality, and quality of life in people with multiple sclerosis MS. This randomized controlled trial compares this approach to a conventional high-intensity strengthening program. The study aims to fill the gap in research about BFRTs impact on forearm and hand muscles in individuals with MS and to assess adherence and satisfaction with the intervention. Participants will be randomly assigned to one of two groups a control group performing a conventional high-intensity strengthening program using dumbbells at 70% of one repetition maximum 1RM with 4 sets of 8-12 repetitions, and an experimental group performing a low-intensity strengthening program at 20% 1RM combined with the BFRT system. The BFRT will be applied via an external pneumatic tourniquet at 60% of the total restriction pressure TRP during exercises involving palmar flexion, dorsal flexion, ulnar deviation, radial deviation, pronation, supination, and elbow flexion and extension. Each session includes rest periods based on fatigue. Participants will undergo assessments before, immediately after, and during follow-up up to 8 weeks. Evaluations include isometric hand strength, coordination tests, functional status of the upper limb, quality of life questionnaires, and satisfaction surveys. Researchers will monitor safety, feasibility, and adherence throughout the study, which is scheduled to start in March 2025 and run until December 2026. The total number of participants planned is 21, accounting for possible dropouts.

Blood Flow Restriction for Upper Limb Rehabilitation in People With Multiple Sclerosis. A Randomized Controlled Trial (BFRT-EM)