Actively Recruiting
Blood Pressure Reduction to Limit the Evolution of Vascular Brain Lesions in Elderly Individuals
Led by Assistance Publique - Hôpitaux de Paris · Updated on 2025-09-05
820
Participants Needed
2
Research Sites
679 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of the study is to test the hypothesis of slowing the progression of White Matter Lesions (WML) by lowering blood pressure (BP) in patients with cognitive complaints and a moderate to high grade of WML on brain MRI.
CONDITIONS
Official Title
Blood Pressure Reduction to Limit the Evolution of Vascular Brain Lesions in Elderly Individuals
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 60 and 88 years
- Cognitive complaints with a Mini-Mental State Examination (MMSE) score of 20 or higher within 6 months before enrollment
- Socio-educational level of 3 or higher
- Moderate to high grade white matter hyperintensities on recent MRI or old scan (grades C and D on modified Scheltens scale or grades 2/3 Fazekas)
- Hypertension defined as systolic and/or diastolic blood pressure of 140/90 mmHg or higher, treated or untreated
- Affiliation to a social security system
- Signed informed consent
You will not qualify if you...
- Severe orthostatic hypotension defined as a drop of 30 mmHg in systolic blood pressure within 3 minutes of standing
- Contraindications to MRI such as ferromagnetic foreign bodies, pacemakers, or claustrophobia
- Severe diseases with life expectancy less than 3 months
- Major physical impairments affecting test feasibility (e.g., severe sight or hearing problems)
- Dementia types other than Alzheimer's, vascular dementia, or mixed dementia
- Persons under legal guardianship
- Secondary hypertension causes like renovascular hypertension, primary aldosteronism, or pheochromocytoma
- Already receiving 4 or more antihypertensive drugs at maximum doses
- Participation in another drug clinical research study requiring exclusion
- Severe renal impairment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Memory for Research and Resources Center / Neuroscience pole
Bordeaux, Pellegrin Hospital Group, France, 33076
Not Yet Recruiting
2
Memory Resources Centre and South of Ile de France Search - Broca Hospital
Paris, France, 75013
Actively Recruiting
Research Team
O
Olivier HANON, MD, PhD
CONTACT
C
Christophe TZOURIO, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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