Actively Recruiting
Blood Pressure Slopes and Ultrafiltration in Hemodialysis Patients
Led by VA Office of Research and Development · Updated on 2026-01-07
69
Participants Needed
1
Research Sites
281 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Kidney failure has been recognized as one of the most costly chronic conditions among United States Veterans. Approximately 13,000 Veterans develop kidney failure each year, and most require hemodialysis initiation. Hemodialysis patients suffer significantly increased risk of death and hospitalizations, and excessive body fluid is a major cause of this. While empiric aggressive fluid removal during dialysis is one approach to limit fluid overload, this can cause dangerous decreases in blood pressure during dialysis that independently contribute to the high death rate. In this study, I aim to test a new strategy that prescribes fluid removal based on a patient's recent blood pressure patterns during dialysis. This clinical trial will compare my strategy to standard care and assess the outcomes of overall blood pressure change between dialysis treatments in addition to the number of times the blood pressure becomes dangerously low during dialysis. Another aim is to determine how differences in the structure and function of the heart influence blood pressure during dialysis.
CONDITIONS
Official Title
Blood Pressure Slopes and Ultrafiltration in Hemodialysis Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Hemodialysis patient
- Average pre-dialysis systolic blood pressure greater than 140 mmHg over 2 weeks OR average post-dialysis systolic blood pressure greater than 130 mmHg over 2 weeks
You will not qualify if you...
- Hemodialysis treatment for less than 2 months
- Pregnancy
- Mean systolic blood pressure nadir less than 95 mmHg during 2 weeks screening
- Mean pre- or post-dialysis systolic blood pressure over 180 mmHg
- Mean decrease in blood pressure greater than 60 mmHg from pre- to post-dialysis
- Routine use of clonidine during dialysis
- Routine use of midodrine during dialysis
- Known non-adherence to antihypertensive medication
- Mean ultrafiltration rate greater than 13 mL/kg/hour during 2 week screening
- For bioimpedance measurements only: amputation of a major limb, presence of cardiac defibrillator or pacemaker, or presence of metallic implant such as prosthetic joint
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
VA North Texas Health Care System Dallas VA Medical Center, Dallas, TX
Dallas, Texas, United States, 75216-7167
Actively Recruiting
Research Team
P
Peter N Van Buren, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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