Actively Recruiting
Blood Pressure Variability and Ischemic Stroke Outcome
Led by Yale University · Updated on 2025-07-03
150
Participants Needed
3
Research Sites
89 weeks
Total Duration
On this page
Sponsors
Y
Yale University
Lead Sponsor
U
University of Chicago
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this observational study is to evaluate the role of blood pressure (BPV) variability in patients suffering from acute ischemic stroke. The main questions it aims to answer are: 1. To determine the association of BPV with functional/cognitive outcome after ischemic stroke. 2. To determine a pathophysiologic mechanism of BPV's deleterious effect on functional outcome. 3. To evaluate potential treatment targets to pharmacologically reduce BPV after ischemic stroke.
CONDITIONS
Official Title
Blood Pressure Variability and Ischemic Stroke Outcome
Who Can Participate
Eligibility Criteria
You may qualify if you...
-
Ischemic stroke according to the American Heart Association (AHA) definition and either:
-
CT or MRI showing ischemic stroke in the anterior circulation (frontal, parietal or superior temporal lobes), or
-
Occlusion of the internal carotid, middle cerebral or anterior cerebral arteries on computed tomography angiography (CTA) or magnetic resonance angiography (MRA)
Onset of ischemic stroke within 48 hours and able to get baseline pMRI within 72 hours of arrival
4) NIH Stroke Scale ≥ 4 at time of enrollment
-
You will not qualify if you...
- Pre-morbid mRS ≥3
- Predicted hospital system admission <72 hours
- Pacemaker or other MRI contraindications per American College of Radiology guidelines
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 3 locations
1
Yale-New Haven Hospital
New Haven, Connecticut, United States, 06510
Actively Recruiting
2
University of Chicago Medical Center
Chicago, Illinois, United States, 60637
Actively Recruiting
3
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
Actively Recruiting
Research Team
A
Adam de Havenon, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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