The importance of the 2S albumins for allergenicity and cross-reactivity of peanuts, tree nuts, and sesame seeds.
Stephen C Dreskin, Stef J Koppelman, Sandra Andorf...
https://pubmed.ncbi.nlm.nih.gov/33217410Actively Recruiting
Age: 1Year - 75Years
All Genders
Healthy Volunteers
ID02192866
Blood Samples for the Study of Peanut, Tree Nut and Other Food Allergies
Led by University of Colorado, Denver · Updated on 2022-12-19
270
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
U
University of Colorado, Denver
Lead Sponsor
N
National Institutes of Health (NIH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This research aims to understand peanut, tree nut, and other food allergies by studying blood samples from people with these allergies and from those without. The study collects blood and health history from participants treated for peanut allergies or undergoing oral food challenges at multiple institutions. The goal is to develop lab tests predicting allergic reaction severity, identify allergenic peanut components, find prevention methods, and explore strong walnut proteins. Blood samples, including serum, plasma, and cells, are collected from participants with specific food allergies and controls. Existing de-identified samples and cord blood are also used. The study involves no therapeutic treatments but focuses on drawing blood and processing samples for laboratory experiments investigating immune responses and allergic proteins. Participants provide a single blood sample and share health history. Researchers analyze these samples to identify traits linked to severe allergies through tests like basophil activation and IgE binding. Personal information is removed from many samples to protect privacy. The study includes participants aged 1 to 75 and continues until December 2030, with no direct interventions or treatments given during participation.
CONDITIONS
Brief Title
Blood Samples for the Study of Peanut, Tree Nut and Other Food Allergies
Who Can Participate
Age: 1Year - 75Years
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Patients enrolled in a controlled trial of oral immunotherapy (OIT) for peanuts with at least one oral challenge, aged 1 to 75
- Patients undergoing clinically indicated food challenges for peanut allergy, aged 1 to 75
- Patients with a clear history of systemic reaction to peanuts, aged 6 to 75
- Patients with a clear history of systemic reaction to tree nuts or other foods, aged 6 to 75
- Normal controls with no known food allergies, recent ingestion of peanuts without issues, aged 6 to 75
You will not qualify if you...
- Any known significant medical or psychiatric diagnosis
- Use of an investigational drug within 30 days
- Use of omalizumab (anti-IgE; Xolair) within 6 months
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Sample Collection
Duration - 1 day
Participants provide blood samples for the study of peanut, tree nut, and other food allergies. This involves a single blood draw to collect serum, plasma, and cells for research purposes.
1 visit (in-person)
Trial Site Locations
Total: 1 location
1
University of Colorado School of Medicine
Denver, Colorado, United States, 80045
Actively Recruiting
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Research Team
S
Stephen Dreskin, MD, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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Published Research Related To This Trial
Immunodominant conformational and linear IgE epitopes lie in a single segment of Ara h 2.
Stéphane Hazebrouck, Sarita U Patil, Blanche Guillon...
https://pubmed.ncbi.nlm.nih.gov/35150723The Effector Function of Allergens.
Stéphane Hazebrouck, Nicole Canon, Stephen C Dreskin
https://pubmed.ncbi.nlm.nih.gov/35386644IgE binding to linear epitopes of Ara h 2 in peanut allergic preschool children undergoing oral Immunotherapy.
Stephen C Dreskin, Matthew Germinaro, Dominik Reinhold...
https://pubmed.ncbi.nlm.nih.gov/31437325