Actively Recruiting
Blood and Tissue Markers for Improving Diagnosis and Prognosis of Endometriosis. (ENDOBIO)
Led by Region Stockholm · Updated on 2025-02-24
345
Participants Needed
3
Research Sites
191 weeks
Total Duration
On this page
Sponsors
R
Region Stockholm
Lead Sponsor
K
Karolinska Institutet
Collaborating Sponsor
AI-Summary
What this Trial Is About
Endometriosis is a chronic, benign, estrogen-dependent disease characterized by endometrial tissue that is implanted outside the uterus into the ovaries, intestines, or peritoneum but also outside the pelvis. It is a common disease that affects 7-10% of women around the world. The most common symptoms are pain and infertility. The diagnosis is histological after removal of lesions with laparoscopy (sensitivity 94%, specificity 79%), and treatment is symptomatic. At present, there is not a laboratory test that allows early and adequate diagnosis of endometriosis and therefore it can take up to 10 years for a patient to be diagnosed and patients often suffer from the disease. The purpose of our study is to investigate biomarkers associated with endometriosis and prove their use in the diagnosis and staging of endometriosis. The biomarkers will be studied even in relationship to clinical manifestations of the disease, as markers of relapse and as fertility markers. Meanwhile, quality of life of patients with advanced stages of endometriosis postoperatively will be studied.
CONDITIONS
Official Title
Blood and Tissue Markers for Improving Diagnosis and Prognosis of Endometriosis. (ENDOBIO)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women aged 18 to 45 years
- Undergoing surgery due to suspected endometriosis symptoms such as pain or infertility (patient group)
- Undergoing surgery for other benign gynecological reasons without visible endometriosis confirmed by biopsies (control group)
- Able to speak Swedish or English to complete questionnaires and provide informed consent
You will not qualify if you...
- Body mass index over 40
- Postmenopausal women
- Premature ovarian failure
- Pelvic inflammatory disease
- Current or previous cancer
- Pregnancy or within 6 months postpartum
- Use of corticosteroids in the last 3 months
- Diseases of the pituitary, kidney, liver, or adrenal glands
- Endometrial hyperplasia or endometrial polyps
- Cardiovascular or systemic inflammatory diseases
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
Karolinska Universitetssjukhus Huddinge
Stockholm, Huddinge, Sweden
Actively Recruiting
2
Södersjukhuset Kvinnokliniken
Stockholm, Stockholm County, Sweden
Actively Recruiting
3
Akademiska Uppsala
Uppsala, Sweden
Not Yet Recruiting
Research Team
A
Anastasia Drakou, MSc
CONTACT
K
Kenny Rodriguez-Wallberg, Professor
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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