Actively Recruiting
Blood Tuberculosis DNA Levels to Monitor Tuberculosis Treatment
Led by University of Oxford · Updated on 2026-04-13
140
Participants Needed
1
Research Sites
114 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Tuberculosis (TB) is a leading infectious cause of death worldwide. Current strategies for monitoring TB treatment response are culture dependent and insensitive. New methods of assessing treatment response in vivo could inform new drug development and other treatment strategies. Cell-free DNA (cfDNA) - small circulating fragments of DNA - is widely used in maternofetal medicine and oncology for diagnosis and assessment of treatment response. This study aims to investigate whether pathogen derived Mycobacterium tuberculosis-specific cfDNA (Mtb-cfDNA) can be used to monitor TB treatment response. This feasibility study will take place at Mae RaMat TB Center in Thailand and includes two study groups: 1. Assay Development and Validation 2. Longitudinal Assessment of Mtb-cfDNA levels
CONDITIONS
Official Title
Blood Tuberculosis DNA Levels to Monitor Tuberculosis Treatment
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants aged 18 years or older
- Newly diagnosed with microbiologically confirmed tuberculosis infection (any site)
- Have not started antituberculosis treatment
- Able to understand study procedures and provide informed consent
- Healthy volunteers aged 18 years or older judged healthy by a physician
- Healthy volunteers able to understand study procedures and provide informed consent
You will not qualify if you...
- Exposure to antituberculosis treatment or active fluoroquinolone use within the last 8 weeks
- Known history of malignancy
- Pregnancy
- Transfusion dependent anemia
- Healthy volunteers with history of tuberculosis infection or latent infection
- Healthy volunteers who are close contacts of persons with tuberculosis
- Healthy volunteers with chest X-ray changes suggesting pulmonary tuberculosis
- Healthy volunteers with symptoms indicating possible tuberculosis (cough over 2 weeks, fever, weight loss, night sweats)
- Healthy volunteers with other major medical conditions
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Shoklo Malaria Research Unit (SMRU)
Tak, Thailand
Actively Recruiting
Research Team
H
Htet Ko Ko Aung, Dr
CONTACT
F
François Nosten, Professor
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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