Actively Recruiting
BLOOM: Pragmatic Feasibility Trial
Led by Mayo Clinic · Updated on 2026-02-06
300
Participants Needed
1
Research Sites
76 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this study is to compare two different ways of dosing cefepime, an antibiotic for very sick patients - the usual approach to dosing or a new dosing method. The new dosing method uses only doses that are available in normal care, but choosing between the different doses is based on more information about the patient's body including their kidney function. The primary purpose of this study is to test how easy it is for healthcare professionals to use the new dosing method and how best to conduct the trial. The study will also assess if the new dosing method helps patients recover faster and reduces side effects.
CONDITIONS
Official Title
BLOOM: Pragmatic Feasibility Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults 6518 years of age
- Admitted to one of the ICUs at the study center
- Prescribed cefepime therapy by the care team
You will not qualify if you...
- Allergy to cephalosporin antibiotics
- Received more than 1 dose of cefepime in the 24 hours before ICU admission
- Transferred from an external hospital without compatible electronic health records
- Missing cystatin C or creatinine lab results needed for dosing
- Acute kidney injury stage 2 or higher
- Receiving renal replacement therapy
- Treated with extracorporeal membrane oxygenation
- Undergoing molecular adsorbent recirculating therapy at beta-lactam initiation
- Pregnant
- Incarcerated
- Declined Minnesota research authorization
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Mayo Clinic in Rochester
Rochester, Minnesota, United States, 55905
Actively Recruiting
Research Team
G
Gerald W. Flaby Jr., LRT, RRT
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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