Photobiomodulation with Blue Light on Wound Healing: A Scoping Review.
Thais P Prado, Flávia Cristina Zanchetta, Beatriz Barbieri...
https://pubmed.ncbi.nlm.nih.gov/36836932/Actively Recruiting
Led by AUSL Romagna Rimini · Updated on 2026-04-06
25
Participants Needed
1
Research Sites
8 weeks
Total Duration
Researchers are evaluating whether blue light BL photobiomodulation can improve healing of donor site wounds in adult patients with intermediate or deep burn injuries treated surgically. The study aims to find out if adding BL therapy to standard care reduces healing time, improves wound conditions, reduces pain and infection signs, is safe, and enhances long-term scar quality. Burn injuries often require skin grafting, and donor sites can have complications that affect healing and patient comfort. Participants will receive standard wound care on both donor sites, with one site also receiving weekly BL therapy using a medical device for 60 seconds per session over 3-4 weeks. The donor site on the right side will get BL plus standard care, while the left side will receive only standard care. This intra-patient controlled design allows direct comparison of healing between treated and untreated areas within the same patient. During the treatment period, participants will have weekly clinical evaluations including wound observation, pain assessments, skin swabs for infection, and photographic documentation. After complete healing, follow-up visits at 1 and 3 months will assess scar quality and check for late side effects. Safety monitoring will record any adverse reactions related to the blue light treatment throughout the study. The total study duration per participant spans about 4-5 weeks of treatment plus follow-up.
CONDITIONS
Blue Light for Donor Site Healing in Burn Patients
J
Jutta Renate Lehmann, Dr.
D
Davide Griffa, Dr.
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AUSL Romagna Rimini
Lead Sponsor
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Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 screening and enrollment visit (in-person)
Duration - Approximately 3 to 4 weeks depending on healing progression
Participants receive standard wound care on both donor site areas; one area also receives blue light therapy once per week to promote healing.
Weekly visits for dressing changes and clinical evaluations
Duration - Up to 3 months after healing
Participants return for follow-up visits to evaluate scar quality and monitor for late adverse events after wound healing.
2 visits at 1 month and 3 months post-healing (in-person or outpatient clinic)
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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