Actively Recruiting
Body Composition and Exercise to Prevent Muscle Loss With GLP1 Agonist Treatment
Led by Massachusetts General Hospital · Updated on 2025-12-30
100
Participants Needed
1
Research Sites
79 weeks
Total Duration
On this page
Sponsors
M
Massachusetts General Hospital
Lead Sponsor
S
Samsung
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this study is to learn if a smartwatch that measures activity level and body composition, combined with exercise reminders, can safely improve strength and muscle mass in people who recently started or are planning to start treatment with incretin therapy (liraglutide, semaglutide, tirzepatide or retatrutide), also known as glucagon-like peptide 1 receptor agonist (GLP-1 RA) medications.
CONDITIONS
Official Title
Body Composition and Exercise to Prevent Muscle Loss With GLP1 Agonist Treatment
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older at time of signing informed consent
- Started treatment with incretin therapy (liraglutide, semaglutide, tirzepatide, or retatrutide) within the past 2 months or planning to start this treatment
- Switching GLP1-RA therapies due to inadequate prior response are eligible
- Able to provide informed consent
You will not qualify if you...
- Current pregnancy or plans to become pregnant in the next 6 months
- Body mass index (BMI) less than 25 kg/m2 at screening
- Unable to participate in a regular physical exercise program
- Implanted pacemaker
- Any factors that would interfere with safe completion of the study as judged by the principal investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Diabetes Research Center
Boston, Massachusetts, United States, 02114
Actively Recruiting
Research Team
B
Ben O Brenner, BS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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