A novel non-invasive method to detect excessively high respiratory effort and dynamic transpulmonary driving pressure during mechanical ventilation.
Michele Bertoni, Irene Telias, Martin Urner...
https://pubmed.ncbi.nlm.nih.gov/31694692/Actively Recruiting
Led by University of Pernambuco · Updated on 2026-01-09
30
Participants Needed
1
Research Sites
N/A
Total Duration
This research aims to understand how different body positions affect breathing effort, lung ventilation, and air distribution in critically ill adults who are on mechanical ventilation. It focuses on assessing the effects of Automatic Lateralization Therapy on respiratory drive and lung function compared to standard supine positioning. The study also evaluates whether combining this therapy with Flow Bias enhances respiratory and functional outcomes. The study is a quasi-experimental, non-randomized physiological intervention conducted in an ICU setting.
CONDITIONS
Body Lateralization and Its Effects on Respiratory Drive, Ventilation, and Pulmonary Aeration in Critically Ill Patients
S
Shirley Lima Campos, PhD
E
Emanuel Fernandes Ferreira da Silva Júnior, MSc
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University of Pernambuco
Lead Sponsor
Universidade Federal de Pernambuco
Collaborating Sponsor
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Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Unilateral: 140 minutes (2 hours 20 minutes); Bilateral: 370 minutes (6 hours 10 minutes)
Participants undergo body positioning interventions including supine positioning with head elevation and automatic lateralization therapy with progressive body tilt angles. These interventions aim to evaluate respiratory drive activation, ventilation, and pulmonary aeration while being monitored for safety.
1 continuous intervention session per participant
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
NON_RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
2
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https://pubmed.ncbi.nlm.nih.gov/25886857/University of Pernambuco
Lead Sponsor
Universidade Federal de Pernambuco
Collaborating Sponsor