A Novel Pacing Strategy With Low and Stable Output: Pacing the Left Bundle Branch Immediately Beyond the Conduction Block.
Weijian Huang, Lan Su, Shengjie Wu...
https://pubmed.ncbi.nlm.nih.gov/29173611Actively Recruiting
Age: 18Years +
All Genders
ID06540521
Intracardiac Electrical Characteristics of Left Bundle Branch Area Pacing in Heart Failure and Bradycardia
Led by Medtronic Cardiac Rhythm and Heart Failure · Updated on 2025-09-29
75
Participants Needed
2
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating the electrical features of the heart during different pacing outputs and body positions in left bundle branch area pacing (LBBAP). This study aims to help develop and validate a new algorithm to better identify left bundle branch (LBB) capture during LBBAP, which may improve understanding of heart pacing effects. The study focuses on patients with heart failure or bradycardia who have received LBBAP therapy. The study observes patients who have had LBBAP therapy for 1 to 4 months and have devices capable of providing real-time intracardiac electrograms. There is no active treatment or intervention involved. The study monitors electrical characteristics under various pacing outputs and body positions, aiming to differentiate between LBB capture and left ventricular septal pacing (LVSP). Participants will be followed from 1 month up to 4 months after receiving LBBAP therapy, with an optional follow-up at 6 months after enrollment. During this time, researchers will collect data on intracardiac electrical signals and their correlation with ECG findings. No additional treatments are given; the study focuses on collecting and analyzing heart electrical activity to understand pacing effects and improve pacing methods.
CONDITIONS
Brief Title
Bolt CSP-M Holter Study
Who Can Participate
Age: 18Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Patients aged 18 years
- Patients willing to provide informed consent
- Patients who have received LBBAP therapy for 1 to 4 months (including 1 and 4 months)
- Patients implanted with a single-chamber, dual-chamber pacemaker, or CRT-P with LBBAP lead connected to the right ventricle port
- Implanted device capable of providing at least 3-channel real-time intracardiac electrograms
You will not qualify if you...
- Patients who are pregnant or planning pregnancy during the study
- Patients with medical conditions that would limit study participation
- Patients already enrolled in clinical trials that could impact participation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Surveillance
Duration - 1 to 4 months
Participants who have received LBBAP therapy for 1 to 4 months are observed to assess intracardiac electrical characteristics under different pacing outputs and body positions.
1 to 4 visits depending on duration
Long-term Monitoring
Duration - Up to 6 months after enrollment
Optional follow-up visit approximately 6 months after enrollment to evaluate ongoing intracardiac electrical characteristics and correlation with LBB capture status.
1 follow-up visit (in-person)
Trial Site Locations
Total: 2 locations
1
Shanghai Chest Hospital
Shanghai, Shanghai Municipality, China
Actively Recruiting
2
Zhejiang Greentown Cardiovascular Hospital
Hangzhou, Zhejiang, China
Not Yet Recruiting
Loading map...
Research Team
S
Simon Cao, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here
Published Research Related To This Trial
Differentiating left bundle branch pacing and left ventricular septal pacing: An algorithm based on intracardiac electrophysiology.
Xing Chen, Zhiyong Qian, Fengwei Zou...
https://pubmed.ncbi.nlm.nih.gov/34978368Left ventricular septal pacing versus left bundle branch pacing in the treatment of atrioventricular block.
Yu Zhou, Jinfeng Wang, Youquan Wei...
https://pubmed.ncbi.nlm.nih.gov/35267228Evaluation of the Criteria to Distinguish Left Bundle Branch Pacing From Left Ventricular Septal Pacing.
Shengjie Wu, Xueying Chen, Songjie Wang...
https://pubmed.ncbi.nlm.nih.gov/33933414