Study of Resistance Training, Alendronate, and Diet to Prevent Bone Loss During Weight Loss in Older Adults

What this Trial Is About

Researchers are exploring ways to reduce bone loss that happens when older adults lose weight. This study focuses on older adults with low bone density who are advised to lose weight, aiming to compare the effects of resistance training combined with bone-loading exercises and a medication called bisphosphonate. The goal is to understand which strategies best protect bone health during weight loss over a 12-month period. Participants are randomly assigned to one of four groups resistance training plus weekly bisphosphonate, bisphosphonate alone, resistance training plus a placebo, or placebo alone. All participants follow the same dietary weight loss program. Resistance training involves supervised exercise sessions three times a week using machines suitable for older adults. The medication is given weekly, and placebo capsules match the medication in appearance and schedule. Participants will attend up to nine assessment visits over two years. Bone density and quality will be measured using dual x-ray absorptiometry and high-resolution CT scans at various skeletal sites including the hip, femoral neck, lumbar spine, radius, and tibia. Researchers will track changes in bone mineral density and microarchitecture to evaluate treatment effects. Safety and adherence will be monitored throughout the study, which is expected to complete by early 2028.

Bone, Exercise, Alendronate, and Caloric Restriction