Impact of Sleeve Gastrectomy on Bone Health in Adults with Type 2 Diabetes and Obesity Comparison with Overweight Adults Without Diabetes

What this Trial Is About

Researchers are studying the effects of sleeve gastrectomy, a popular weight loss surgery, on bone health in adults with type 2 diabetes. The study aims to see how this surgery impacts volumetric bone mineral density vBMD and to compare these effects with those in obese patients without diabetes and overweight individuals without diabetes or obesity. The goal is to understand how diabetes and bariatric surgery together affect bone strength over time. The study is observational and includes two groups 70 adults with obesity undergoing sleeve gastrectomy, some with type 2 diabetes and some without, and 30 overweight adults without diabetes serving as controls. Participants in the surgery group are evaluated before surgery and again at 4 months, 8 months, 1 year, and 3 years after the procedure. The control group is assessed once. The main treatment studied is the sleeve gastrectomy surgery, and its impact on bone and metabolic health is monitored. Participants will undergo various tests and assessments including quantitative computed tomography QCT scans to measure bone density at the spine, hip, tibia, and radius before surgery and during follow-up visits. Blood tests will track bone turnover markers, glucose control, and hormone levels. Body composition, muscle strength, physical activity, nutrition, and gut microbiota will also be measured at multiple timepoints. Researchers will monitor changes over three years to evaluate long-term bone health and related factors in this population.

Bone Health After Bariatric Surgery in Patients With Type 2 Diabetes