Actively Recruiting
Bone Marrow Derived Stem Cells Mobilization for Treatment of Abnormal Endometrium
Led by Hugh Taylor · Updated on 2025-11-12
90
Participants Needed
1
Research Sites
213 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study will assess the use of autologous bone marrow stem cells mobilization using 1,1'-\[1,4-phenylenebis-(methylene)\]-bis-1,4,8,11-tetraazacyclotetradecane (PLERIXAFOR) as an effective medical therapy for the treatment of Asherman's Syndrome (AS), Atrophic Endometrium (AE) and Recurrent Implantation Failure (RIF).
CONDITIONS
Official Title
Bone Marrow Derived Stem Cells Mobilization for Treatment of Abnormal Endometrium
Who Can Participate
Eligibility Criteria
You may qualify if you...
-
Healthy, non pregnant females
-
ages ≥18 and ≤40 years old at time of enrollment
-
with either AS, AE, or RIF
- For AS: surgical history of intrauterine trauma/infection, hypo/amenorrhea, intra-uterine adhesions
- for AE: US documentation of persistent, <6mm endometrial thickness
- for RIF: failure to achieve a clinical pregnancy after transfer of at least four good-quality embryos in a minimum of three fresh or frozen cycles in a woman under 40 years and currently being treated at Yale Fertility Clinic
You will not qualify if you...
- Presence of hydrosalpinx (diagnosed by radiographic or ultrasound imaging)
- Endometriosis (diagnosed by previous surgery,)
- Diminished ovarian reserve (AMH<1ng/ml or follicle stimulating hormone (FSH)>10)
- History of genital tuberculosis or any ultrasound evidence of congenital uterine anomaly
- Submucous or intracavitary fibroid, polyps
- Currently pregnant
- Personal history of thrombophilia or sickle cell disease
- Inability to provide informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Yale Fertility Center
Orange, Connecticut, United States, 06477
Actively Recruiting
Research Team
H
Hugh S Taylor, MD
CONTACT
M
Michele Frank, BSN
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here