Study of Immune Responses to Seasonal Influenza Vaccine in Healthy Adults Ages 18 to 64

What this Trial Is About

Researchers are studying how the immune system responds to the seasonal flu vaccine in healthy adults aged 18 to 64. This study aims to understand the strength, variety, and duration of the bodys immune response after receiving the inactivated flu vaccine. The research is important because flu infection can cause serious illness, and learning about immune responses may help improve future vaccines. Participants will receive one dose of an FDA-approved seasonal flu vaccine through an injection in the arm. The study is open-label and observational with no placebo or comparison group. Volunteers can participate for up to three consecutive years if they continue to meet eligibility criteria and agree to re-consent each year. The study lasts up to one year per participant, with blood and bone marrow samples collected at multiple time points after vaccination. During their participation, volunteers will have blood and bone marrow samples taken before vaccination and at 7, 28, 90, and 365 days afterward. These samples will help researchers measure changes in B-cell responses, which are part of the immune systems defense. Participants will be monitored for the persistence and diversity of these immune responses. The study will last seven years in total, enrolling up to 90 healthy volunteers, with opportunities to re-enroll yearly if eligible.

Bone Marrow and Peripheral Blood Immune Responses Study