Actively Recruiting
Bone Marrow and Peripheral Blood Immune Responses Study
Led by Emory University · Updated on 2024-01-31
90
Participants Needed
1
Research Sites
319 weeks
Total Duration
On this page
Sponsors
E
Emory University
Lead Sponsor
N
National Institute of Allergy and Infectious Diseases (NIAID)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to evaluate the immune response of the killed flu vaccine in healthy subjects. Participants in this study are considered to be healthy volunteers. Influenza ("Flu") infection carries a risk of serious illness. This is an open label and single arm observational study designed to assess the humoral response to influenza vaccination and the longevity of humoral immunity to influenza vaccination in healthy adults. Enrolled subjects will receive licensed seasonal inactivated influenza vaccine (administered as a part of the study). Participants will donate serial samples of blood and bone marrow aspirate for immunology monitoring. Repeated measurements of humoral immunity will be obtained at 7 days, 28 days, 90 days and at one year post vaccination to assess the magnitude, clonal diversity and persistence of B-cell responses to influenza vaccination.
CONDITIONS
Official Title
Bone Marrow and Peripheral Blood Immune Responses Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 64 years
- All genders, races, and ethnic groups are eligible
- Able to provide informed consent independently
- Healthy adults
You will not qualify if you...
- Unable to provide informed consent
- Pregnant or nursing women
- Prisoners
- Cognitively impaired individuals or those with impaired decision-making capacity
- Vulnerable populations such as human fetuses, neonates of uncertain viability, non-viable neonates, minors/children, and cognitively impaired adults
AI-Screening
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Trial Site Locations
Total: 1 location
1
Emory University Hospital
Atlanta, Georgia, United States, 30322
Actively Recruiting
Research Team
J
Jennifer C Truell, MA, MPH
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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