Study Comparing Bone and Muscle Health Changes After Sleeve Gastrectomy in Men and Women Before and After Menopause

What this Trial Is About

This research focuses on understanding the effects of sleeve gastrectomy, a popular weight loss surgery, on bone and muscle health in adults with obesity. It compares changes in bone mineral density and muscle mass over three years among men, premenopausal women, and postmenopausal women who undergo the surgery, against similar individuals who do not have the surgery. The study aims to assess the risks of bone loss and muscle strength reduction that may occur after this procedure, which is important given concerns about fractures and falls following older types of bariatric surgeries. Participants are divided into four groups men, premenopausal women, postmenopausal women undergoing sleeve gastrectomy, and a non-surgical group of obese individuals. The study observes changes in spine and femur bone density using quantitative computed tomography and dual-energy X-ray absorptiometry, alongside assessments of muscle mass, quality, and strength. Measurements are taken before surgery, then one year and three years after surgery, to track progress and compare results between surgical and non-surgical groups. Throughout the study, participants will undergo scans and tests to measure bone density and muscle condition, including physical performance evaluations that predict risk of falls and fractures. These assessments are planned at baseline, 1 year, and 3 years after surgery. Researchers monitor changes over time to understand the long-term impact of sleeve gastrectomy on bone and muscle health. The total participation time spans three years, with ongoing evaluation of outcomes related to bone mineral density and muscle mass at specific skeletal sites.

Bone and Muscle Health Following Sleeve Gastrectomy in Men, Premenopausal and Postmenopausal Women