Actively Recruiting
Bone Reconstruction With Autologous Bone Marrow Mesenchymal Stem Cells in Vitro to Repair Long Tubular Bone Defects
Led by The First Affiliated Hospital of Xinxiang Medical College · Updated on 2026-01-02
30
Participants Needed
1
Research Sites
173 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Commercial decalcified bone scaffolds were combined with autologous bone marrow mesenchymal stem cells to form tissue engineered bone in vitro to explore the effect of this tissue engineered bone in the clinical repair of long tubular bone defects in limbs.
CONDITIONS
Official Title
Bone Reconstruction With Autologous Bone Marrow Mesenchymal Stem Cells in Vitro to Repair Long Tubular Bone Defects
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 to 55 years, any gender
- Defective nonunion with bone loss over 30% of bone cross-section and length of 2-3 cm
- Solitary bone cysts involving more than 50% of the bone cross-section
You will not qualify if you...
- Presence of local tumors, tuberculosis, infections, or other lesions affecting bone healing
- Systemic diseases impacting bone healing such as osteofibrous dysplasia, osteogenesis imperfecta, bone dystrophic diseases, or metabolic bone disorders
- Moderate to severe osteoporosis (T-score less than -2.5)
- Severe systemic conditions including malnutrition, systemic infections, severe heart or lung diseases, coagulation disorders, or organ failure
- Severe brain trauma
- Heavy smoking, drug abuse, alcoholism, or other harmful addictions
- Psychiatric disorders or menopausal symptoms
- Participation in other clinical trials within the past 4 weeks or currently
- Pregnancy, breastfeeding, or planned pregnancy within one year after enrollment
- Psychological conditions impairing treatment compliance
- Congenital malformations of vital organs or other systems
- Nonunion caused by malignant tumor resection
- Refusal to accept tissue-engineered bone repair protocol
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
The First Affiliated Hospital of Xinxiang Medical College
Xinxiang, Henan, China, 453000
Actively Recruiting
Research Team
W
Wenjie Ren
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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