Actively Recruiting
Boosting Open-Label Placebo Effects in Acute Induced Pain in Healthy Adults
Led by University Hospital, Basel, Switzerland · Updated on 2025-01-24
141
Participants Needed
1
Research Sites
114 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is to investigate the effect of open-label placebo (OLP) application on acute pain in an experimental model of acute pain (simulating wound pain: this installation will apply monophasic, rectangular electrical pulses of 0.5ms duration with alternating polarity at 2 Hz frequency. The current will be increased to target a pain rating of 6 of 10 on the NRS (0 = no pain, 10 = worst imaginable pain). Three further adjustments in current will be made every 5 minutes for the next 15 minutes to compensate for habituation. This final current will be kept constant until the end of the particular experiment). In Part 1 duration of OLP analgesia will be examined, and onset and size of the effect will be reevaluated. In Part 2 of this study outcomes between subjects receiving one OLP injection, subjects receiving one repetition of the injection on a fixed time point and subjects receiving one repetition of the injection on-demand will be evaluated
CONDITIONS
Official Title
Boosting Open-Label Placebo Effects in Acute Induced Pain in Healthy Adults
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy volunteers (ASA Class I or II), aged 18 to 65 years
- Body mass index (BMI) between 18 and 25 kg/m2
- Able to understand the study and the numeric rating scale (NRS) for pain
- Able to provide informed consent
You will not qualify if you...
- Participation in a previous open-label placebo study, including Part 1 of this study for Part 2 participants
- Regular use of medications or drugs that may interfere with pain sensation, such as analgesics, opioids, antihistamines, calcium and potassium channel blockers, serotonin/noradrenaline reuptake inhibitors, or corticosteroids
- Presence of neuropathy
- Chronic pain conditions
- Neuromuscular diseases
- Dermatological diseases, including atopic dermatitis
- Psychiatric diseases
- Pregnancy or lactation
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University Hospital of Basel (USB); Department of Anaesthesiology
Basel, Switzerland, 4031
Actively Recruiting
Research Team
T
Tobias Schneider, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
OTHER
Number of Arms
5
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