Newborn DNA methylation age differentiates long-term weight trajectories: the Boston Birth Cohort.
Anat Yaskolka Meir, Guoying Wang, Xiumei Hong...
https://pubmed.ncbi.nlm.nih.gov/39256781Actively Recruiting
Age: 0Years - 50Years
All Genders
ID03228875
Early Life Origins of Pediatric and Adult Diseases: Boston Birth Cohort Study
Led by Johns Hopkins Bloomberg School of Public Health · Updated on 2025-09-17
24000
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
J
Johns Hopkins Bloomberg School of Public Health
Lead Sponsor
B
Boston Medical Center
Collaborating Sponsor
AI-Summary
What this Trial Is About
This research aims to understand how early life exposures affect health outcomes in both mothers and children. It focuses on a wide range of factors starting from birth and tracks their impact on pediatric and adult health. The study is observational and investigates pregnancy complications, birth outcomes such as preterm birth and birthweight, as well as long-term child and maternal health up to 21 years after delivery. Participants include women who deliver a single live infant at Boston Medical Center, either preterm or full term with varying birthweights. The study involves enrolling mother-child pairs and following them from birth until the child reaches 21 years of age. Data collection includes high-quality biospecimen sampling, detailed questionnaires, clinical measurements, and review of electronic medical records. Throughout the study, participants undergo comprehensive health assessments and data collection to monitor pregnancy complications at birth, birth outcomes, and ongoing child and maternal health outcomes. Researchers measure these outcomes from birth through 21 years, aiming to identify factors influencing long-term health. The study's long follow-up period allows for extensive observation of health developments in both mother and child.
CONDITIONS
Brief Title
Boston Birth Cohort Study
Who Can Participate
Age: 0Years - 50Years
All Genders
Eligibility Criteria
You may qualify if you...
- Mothers who deliver singleton live births at Boston Medical Center are eligible for the study.
You will not qualify if you...
- Pregnancies resulting from in vitro fertilization are excluded.
- Multiple gestations (twins, triplets, etc.) are excluded.
- Pregnancies with fetal chromosomal abnormalities are excluded.
- Pregnancies with major birth defects are excluded.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Diagnostic Evaluation
Duration - At birth
Participants undergo assessments at birth including collection of biospecimens and clinical data related to pregnancy complications and birth outcomes.
1 visit (in-person)
Long-term Monitoring
Duration - From birth to 21 years
Participants are followed postnatally from birth to age 21 years to monitor child and maternal health outcomes through questionnaires, measurements, and medical record reviews.
Periodic visits over 21 years, including standardized interviews and measurements
Trial Site Locations
Total: 1 location
1
Boston Medical Center
Boston, Massachusetts, United States, 02118
Actively Recruiting
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Research Team
X
Xiaobin Wang, MD, ScD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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Published Research Related To This Trial
Uterine fibroids and risk of hypertensive disorders of pregnancy - results from a racially diverse high-risk cohort.
K Cameron, M Borahay, X Hong...
https://pubmed.ncbi.nlm.nih.gov/38496516Joint Associations of Pregnancy Complications and Postpartum Maternal Renal Biomarkers With Severe Cardiovascular Morbidities: A US Racially and Ethnically Diverse Prospective Birth Cohort Study.
Xiumei Hong, Avi Z Rosenberg, Jurgen Heymann...
https://pubmed.ncbi.nlm.nih.gov/37947096Trimethylamine N-Oxide and Its Precursors Are Associated with Gestational Diabetes Mellitus and Pre-Eclampsia in the Boston Birth Cohort.
Kristen L McArthur, Mingyu Zhang, Xiumei Hong...
https://pubmed.ncbi.nlm.nih.gov/35949367In-utero co-exposure to toxic metals and micronutrients on childhood risk of overweight or obesity: new insight on micronutrients counteracting toxic metals.
Wanyu Huang, Tak Igusa, Guoying Wang...
https://pubmed.ncbi.nlm.nih.gov/35589962Maternal prenatal selenium levels and child risk of neurodevelopmental disorders: A prospective birth cohort study.
Ashley Sang Eun Lee, Yuelong Ji, Ramkripa Raghavan...
https://pubmed.ncbi.nlm.nih.gov/34558795Birth outcomes across the spectrum of maternal age: dissecting aging effect versus confounding by social and medical determinants.
Bolanle Olapeju, Xiumei Hong, Guoying Wang...
https://pubmed.ncbi.nlm.nih.gov/34470614Maternal Hypertensive Disorders in Pregnancy and Postpartum Plasma B Vitamin and Homocysteine Profiles in a High-Risk Multiethnic U.S., Population.
Bolanle Olapeju, Saifuddin Ahmed, Xiumei Hong...
https://pubmed.ncbi.nlm.nih.gov/33252313