Actively Recruiting
Botulinum Toxin Therapy in Hidradenitis Suppurativa
Led by University of Massachusetts, Worcester · Updated on 2025-09-15
20
Participants Needed
1
Research Sites
307 weeks
Total Duration
On this page
Sponsors
U
University of Massachusetts, Worcester
Lead Sponsor
H
Hidradenitis Suppurativa Foundation
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study will build on data from mice and humans implicating TRPV1 nociceptors in the pathogenesis of the type-17 chronic inflammatory skin disease Hidradenitis Suppurativa (HS). In this study, the investigators will test the hypothesis that inhibiting neuropeptide activity with botulinum toxin reduces pathogenic inflammation.
CONDITIONS
Official Title
Botulinum Toxin Therapy in Hidradenitis Suppurativa
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults between ages 18 and 75 years with established diagnosis of hidradenitis suppurativa (HS)
- HS skin lesions of duration at least 1 year
- HS skin lesions in at least two different body areas
You will not qualify if you...
- Age less than 18 years or greater than 75 years
- Pregnant or breastfeeding
- Neuromuscular disorder (ex. ALS, myasthenia gravis, Lambert-Eaton syndrome, myopathy)
- Medical co-morbidity that is a relative contraindication to skin biopsy procedure (ex. end stage congestive heart failure or coagulopathy)
- Active bacterial, fungal, or viral infection in the treatment area
- Known hypersensitivity to botulinum toxin A preparations or any of their components (human albumin, saline, lactose, sodium succinate)
- Prisoners
- Adults unable to consent for themselves.
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University of Massachusetts Chan Medical School
Worcester, Massachusetts, United States, 01605
Actively Recruiting
Research Team
S
Sarah K Whitley, MD PhD
CONTACT
M
Michelle Landry, MPH
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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