Actively Recruiting
Botulinum Toxin for the Treatment of Neurological Disorders
Led by National Institute of Neurological Disorders and Stroke (NINDS) · Updated on 2026-06-08
2000
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying the use of botulinum toxin (BTX) to treat various movement disorders characterized by involuntary muscle spasms. The study focuses on following the natural history of patients receiving standard BTX injections and providing treatment within other NIH research protocols. The goal is to better understand how BTX works across different neurological conditions like dystonia, tremor, and spasticity. Participants 2 years and older with movement disorders that might respond to BTX, such as hemifacial spasm, blepharospasm, tics, or tardive dyskinesia, may be included. Treatment involves BTX injections tailored to each patient's specific disorder and symptoms. The study also trains physicians in specialized injection techniques using tools like EMG and ultrasound guidance. During the study, patients receive regular BTX injections and are monitored over time to maintain a stable response. Researchers collect ongoing data to analyze the natural course of these movement disorders and the effects of BTX treatment. This observational approach helps gather valuable information while patients continue their care with trained providers.
CONDITIONS
Brief Title
Botulinum Toxin for the Treatment of Involuntary Movement Disorders
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients 2 years and older with a movement disorder that might be treatable with botulinum toxin
- Disorders may include dystonia, hemifacial spasm, blepharospasm, tremor, spasmodic dysphonia, tics, vocal fold tremor, oral lingual dyskinesia, tardive dyskinesia, spasticity, and spasmodic dysphonia
You will not qualify if you...
- Women who are planning pregnancy, are pregnant, or breastfeeding during the study
- Subjects currently requiring treatment with an aminoglycoside antibiotic until treatment is finished
- For laryngeal injections, subjects with paradoxical vocal fold movement with intermittent stridor due to gastroesophageal reflux or emotional disorders
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Ongoing
Participants who undergo routine care with botulinum toxin injections for movement disorders are observed.
Visits scheduled as per standard clinical care
Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
Research Team
V
Vivian S Koo
D
Debra J Ehrlich, M.D.
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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