Actively Recruiting
Botulinum Toxin Type A for Frontal Hyperhidrosis
Led by Tishreen University · Updated on 2026-05-01
30
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Frontal hyperhidrosis is a form of primary focal hyperhidrosis that significantly impairs patients' quality of life due to excessive visible sweating in the forehead region. Conventional treatment options often show limited efficacy or may be associated with undesirable side effects. This study aims to evaluate the efficacy and safety of intradermal injections of Botulinum Toxin Type A in patients with primary frontal hyperhidrosis. Clinical outcomes will be assessed using Minor's iodine-starch test, the Hyperhidrosis Disease Severity Scale (HDSS), and patient satisfaction scores. Participants will be followed up one month after treatment to evaluate therapeutic response and potential adverse effects.
CONDITIONS
Official Title
Botulinum Toxin Type A for Frontal Hyperhidrosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged between 18 and 40 years
- Diagnosed with primary focal frontal hyperhidrosis confirmed by sweat production over 50 mg/min and HDSS score of 3 or higher
- Moderate to severe hyperhidrosis as defined by HDSS
- Inadequate response to topical antiperspirant therapy
- No Botulinum toxin type A treatment in the last 6 months
- No other hyperhidrosis treatments used in the last 3 months
You will not qualify if you...
- Secondary hyperhidrosis caused by systemic diseases like hyperthyroidism, diabetes, or neurological conditions
- Neuromuscular disorders such as myasthenia gravis or Lambert-Eaton syndrome
- Active skin conditions or anatomical issues in the forehead area, including infections, inflammation, or scars
- Known allergy to Botulinum toxin or its ingredients
- Pregnancy or breastfeeding
- Use of medications that interfere with Botulinum toxin activity, such as aminoglycosides, within one month before treatment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Latakia University Hospital
Latakia, Syria
Actively Recruiting
Research Team
Z
Zeinab Y Mohammad, MD
CONTACT
M
Mohamad A Ismaiel, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here