Botulinumtoxin A Treatment for Muscle Pain in Temporomandibular Disorders A Study Comparing Different Dose Effects in Adult Women

What this Trial Is About

Researchers are evaluating the use of Botulinum toxin A BTX as a treatment for patients with myogenous temporomandibular disorders TMD, a condition causing muscle-related jaw pain. The study aims to find out if BTX injections in the masseter and temporalis muscles reduce pain and improve quality of life, and if the effect depends on the dose given. It also explores whether different sub-groups of myogenous TMD respond differently to treatment. Participants will receive one of two doses of BTX either 50 units or 100 units, both dissolved in sterile saline and injected into the targeted jaw muscles. This is a randomized study with two groups receiving different doses to compare effects. The treatments are given according to a defined protocol to assess pain relief and other outcomes over time. During the study, participants will be monitored for changes in pain levels, quality of life using the Oral Health Impact Profile questionnaire, jaw opening ability, pressure pain threshold, and psychological factors. These assessments will be conducted over a six-month period to understand the treatment effects. Safety and impact of the doses on pain relief will be closely observed throughout the trial.

Botulinumtoxin A as a Treatment for Myalgia and Myofacial Pain in Patient With Temporomandibulardisorders