Actively Recruiting
Brain Activity Among Children With Overactive Bladder and Daytime Urinary Incontinence and Healthy Children
Led by Aalborg University Hospital · Updated on 2026-04-20
65
Participants Needed
4
Research Sites
343 weeks
Total Duration
On this page
Sponsors
A
Aalborg University Hospital
Lead Sponsor
A
Aarhus University Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
The aim of this study is to investigate whether the activity in brain areas controlling the bladder is different among children suffering from Overactive Bladder (OAB) and Daytime Urinary Incontinence (DUI) compared to age- and gender-matched healthy children without bladder symptoms. Moreover, the aim is to investigate if sacral transcutaneous electric nerve stimulation (TENS) has a central mechanism of action. Children with OAB and DUI will be recruited from involved pediatric departments, and functional magnetic resonance imaging (fMRI) will be performed before and after 10 weeks of sacral TENS. In healthy children without bladder symptoms, only the baseline fMRI will be performed.
CONDITIONS
Official Title
Brain Activity Among Children With Overactive Bladder and Daytime Urinary Incontinence and Healthy Children
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Children aged 6 to 14 years
- Overactive Bladder as defined by International Children's Continence Society criteria (cases only)
- At least 2 urinary incontinence episodes per week (cases only)
- No urinary tract symptoms (healthy participants only)
- More than 3 urinations daily
- Normal clinical examination
You will not qualify if you...
- Known urogenital abnormalities affecting lower urinary tract function
- Prior urinary tract surgery except circumcision
- Known neurological diseases or prior brain surgery
- Known or suspected neuropsychiatric disorders
- Treatment with medications affecting brain function
- Previous treatment with Enuresis Alarm or Transcutaneous Electrical Nerve Stimulation
- Prior or current use of mirabegron or oxybutynin
- Current urinary tract infection
- Current constipation per Rome IV criteria or fecal incontinence
- Claustrophobia
- Presence of metallic items contraindicating MRI
- Abnormal uroflowmetry (healthy participants only)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 4 locations
1
Department of Pediatrics, Aalborg University Hospital
Aalborg, Denmark, 9000
Actively Recruiting
2
Department of Pediatrics, Aarhus University Hospital
Aarhus, Denmark, 8200
Not Yet Recruiting
3
Department of Pediatrics, Regional Hospital West Jutland
Herning, Denmark, 7400
Not Yet Recruiting
4
Department of Pediatrics, North Denmark Regional Hospital
Hjørring, Denmark, 9800
Not Yet Recruiting
Research Team
K
Kristina Thorsteinsson, MD
CONTACT
S
Søren Hagstrøm, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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