Actively Recruiting
Brain Activity During Sexual Behavior in Patients With Primary Premature Ejaculation a Clinical Trial
Led by Xijing Hospital · Updated on 2025-04-17
20
Participants Needed
2
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to compare brain activity during sexual behavior in men with and without primary premature ejaculation, a condition defined by the 2014 International Society for Sexual Medicine criteria. The study uses a controlled design to observe differences between these two groups, focusing on brain function during rest and simulated sexual activity. Participants undergo functional near-infrared spectroscopy (NIRS), a brain imaging technique, to detect brain activity changes in resting and task states. The study includes two groups: men with primary premature ejaculation and men without the condition, matched closely by age. Brain function is monitored during specific tasks related to sexual behavior. During the study, participants will have brain imaging sessions lasting about one hour. Researchers will collect data on brain activity using NIRS during rest and simulated sex tasks. The main outcome measured is the brain imaging results, which will help understand the brain activity differences between the two groups. The study is expected to run until December 2025.
CONDITIONS
Brief Title
Brain Activity During Sexual Behavior in Patients With Primary Premature Ejaculation a Clinical Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male patients aged 18 to 45 years
- Meet 2014 ISSM criteria for primary premature ejaculation (PPE) or are non-PPE matched by age within 3 years
- Stable, heterosexual relationship with a single sexually active female partner for at least 6 months
- At least two sexual intercourses per week, stable during study
- For PPE group: premature ejaculation lasting longer than 6 months
- For PPE group: score higher than 9 on the Chinese version of Premature Ejaculation Diagnostic Tool (PEDT)
- No previous PE therapies or stopped at least 3 months prior
- Signed informed consent form
You will not qualify if you...
- Diagnosis of secondary, variable, or subjective premature ejaculation
- Use of medications for endocrine, metabolic, chronic systemic, or psychiatric diseases
- Alcohol or illegal drug abuse
- Diagnosis of erectile dysfunction with IIEF-5 score less than 21
- Sexual hormone abnormalities, hyperthyroidism, hypothyroidism, Peyronie's disease, prostatitis, urethritis, or urinary tract infection
- Head injuries preventing completion of near-infrared brain imaging
- Severe schizophrenia, anxiety, depression, other neurological symptoms, or poor compliance
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 hour
Participants undergo functional near-infrared spectroscopy to detect brain activity during resting state and task state.
1 visit (in-person)
Trial Site Locations
Total: 2 locations
1
Air Force Military Medical University
Xi'an, Shaanxi, China, 70032
Actively Recruiting
2
Air Force Military Medical University
Xi'an, Shaanxi, China, 70032
Actively Recruiting
Research Team
W
Weijun Qin, M.D
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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