Actively Recruiting
Brain Blood Vessel Responses to Changes in Blood Flow
Led by University of Wisconsin, Madison · Updated on 2026-03-02
36
Participants Needed
1
Research Sites
44 weeks
Total Duration
On this page
Sponsors
U
University of Wisconsin, Madison
Lead Sponsor
N
National Institute of Neurological Disorders and Stroke (NINDS)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Brain blood flow will be measured during a simulated postural change test and while breathing increased levels of carbon dioxide using magnetic resonance imaging.
CONDITIONS
Official Title
Brain Blood Vessel Responses to Changes in Blood Flow
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Between the ages of 55-69 years
- Have a BMI less than or equal to 34.5 kg/m2
- Nonsmoker
- Are less than 72 in (182.88 cm) height
- Females must be postmenopausal
You will not qualify if you...
- Diagnosis of Mild Cognitive Impairment (MCI) or Alzheimer's disease (AD)
- History or evidence of hepatic disease, hematological disease, or peripheral vascular disease; severe kidney injury requiring hemodialysis
- History of cardiovascular disease including: severe congestive heart failure, coronary artery disease, ischemic heart disease (stents, coronary artery bypass grafts) and tachycardia
- Uncontrolled hypertension
- History of clinically significant ischemic or hemorrhagic stroke, or significant cerebrovascular disease
- Severe untreated obstructive sleep apnea
- History of diabetes with HbA1c greater than 9.5%
- Major neurologic disorders other than dementia (e.g., MS, ALS, brain surgery, etc.)
- Current or recent (<1 year) major psychiatric condition (Axis I) or addictive disorders
- Significant surgical history
- Other significant medical conditions at investigators' discretion
- Contraindications to MRI
- Prescribed medications that interfere with prazosin
- Lactose allergy
- Lower body will not fit in lower body negative pressure (LBNP) chamber (regardless of overall height and BMI).
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Wisconsin
Madison, Wisconsin, United States, 53705
Actively Recruiting
Research Team
A
Anna Howery
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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