Actively Recruiting
Brain Changes During Social Reward Psychotherapy for Mid- and Late-Life Suicidality
Led by Weill Medical College of Cornell University · Updated on 2026-03-27
128
Participants Needed
1
Research Sites
262 weeks
Total Duration
On this page
Sponsors
W
Weill Medical College of Cornell University
Lead Sponsor
N
National Institute of Mental Health (NIMH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The investigators hypothesized that during the 9-week course of Engage \& Connect treatment there will be an increase in brain functions of the Positive Valence System which in turn will lead to reduction in suicidality.
CONDITIONS
Official Title
Brain Changes During Social Reward Psychotherapy for Mid- and Late-Life Suicidality
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 50 and 80 years, with 50% of participants older than 65
- Suicidal ideation as measured by the SCID-5 Suicide Item with a score of 2
- Diagnosis of Major Depressive Disorder according to SCID-5
- Montgomery-�c5sberg Depression Rating Scale (MADRS) score of 16 or greater
- Mini Mental Status Exam (MMSE) score of 23 or higher
- Off antidepressants or on a stable dose of antidepressants for at least 8 weeks with no intention to change dose during study
- No individual psychotherapy during the study period
- Ability to provide consent for research and treatment
You will not qualify if you...
- Plans or intent to attempt suicide in the near future
- Psychiatric diagnoses other than Major Depressive Disorder without psychotic features, generalized anxiety disorder, or specific phobia
- Use of psychotropic drugs or cholinesterase inhibitors except lorazepam 0.5 mg or less daily
- Neurological disorders such as dementias, mild cognitive impairment, Parkinson's disease, or epilepsy
- Acute or severe medical illness in past 3 months affecting brain or participation
- Contraindications to MRI scanning including metallic implants or claustrophobia
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Weill Cornell Medicine
New York, New York, United States, 10065
Actively Recruiting
Research Team
N
Nili Solomonov, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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