Actively Recruiting
Brain-Computer Interface Visualization Training to Optimize Muscle Activation Following Orthopaedic Surgery
Led by Rush University Medical Center · Updated on 2025-08-17
240
Participants Needed
1
Research Sites
154 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
After orthopedic surgeries like knee or hip replacement, some patients struggle to fully activate their muscles due to a condition called Arthrogenic Muscle Inhibition (AMI). AMI can slow recovery and make physical therapy less effective. This clinical trial is testing whether a special type of brain training-called neurofeedback visualization training-can help improve muscle activation and speed up recovery. In this study, patients will receive standard physical therapy after surgery. Half of them will also use a device that helps them "visualize" exercises while wearing a cap that reads brain signals (EEG). The cap tracks brain activity when patients imagine doing specific movements. A computer then shows a virtual avatar performing the movements, giving feedback in real time-like a video game controlled by the brain. The study includes patients recovering from one of four surgeries: 1. Anterior cruciate ligament reconstruction (ACLR) 2. Total knee arthroplasty (TKA) 3. Total hip arthroplasty (THA) 4. Hip arthroscopy (HA) for femoroacetabular impingement (FAI) The goal is to see if this training improves muscle strength, movement, and daily function more than standard therapy alone. The study will take place at Rush University Medical Center in Chicago and enroll 240 adults, with 60 patients per type of surgery. Each participant will be followed for up to 6 months after surgery and complete strength tests, movement assessments, and questionnaires about their recovery. The hope is that combining brain training with physical therapy will lead to faster, more complete recoveries and improve how patients move after surgery.
CONDITIONS
Official Title
Brain-Computer Interface Visualization Training to Optimize Muscle Activation Following Orthopaedic Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient age >18 years
- Ability to complete neurofeedback training and follow study follow-ups
- Scheduled for one of the following surgeries: anterior cruciate ligament reconstruction, total knee arthroplasty, total hip arthroplasty, or hip arthroscopy for femoroacetabular impingement
- For ACL reconstruction: primary surgery with autograft or allograft, may include lateral extra-articular tenodesis or meniscus repair
- For total knee arthroplasty: primary surgery with preoperative knee range of motion of at least 100 degrees
- For total hip arthroplasty: primary surgery
- For hip arthroscopy: surgery for femoroacetabular impingement syndrome
You will not qualify if you...
- Inability to participate in neurofeedback training
- Lack of decisional capability
- History of stroke, movement disorder (e.g., Parkinson's), or peripheral neuropathy
- Presence of cardiac pacemaker or other internal electronic device
- Body mass index (BMI) over 35
- Previous surgery or specific pathology on the affected joint
- For ACL reconstruction: revision surgery, moderate to severe arthritis (Kellgren-Lawrence Grade >3), meniscus root repair, or non-weight-bearing status over 1 week postoperatively
- For total knee arthroplasty: revision surgery, hinged implant, open knee procedures, symptomatic arthritis in contralateral knee with planned surgery within 6 months, or inflammatory arthritis
- For total hip arthroplasty: revision surgery, open hip procedures, bilateral hip replacements, or inflammatory arthritis
- For hip arthroscopy: revision surgery or diagnosis of hip dysplasia
AI-Screening
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Trial Site Locations
Total: 1 location
1
Rush University Medical Center
Chicago, Illinois, United States, 60612
Actively Recruiting
Research Team
B
Brian Forsythe, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
8
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