Actively Recruiting
Brain, Emotions, and Mind-Wandering
Led by University of Pittsburgh · Updated on 2025-06-05
140
Participants Needed
1
Research Sites
231 weeks
Total Duration
On this page
Sponsors
U
University of Pittsburgh
Lead Sponsor
N
National Institute of Mental Health (NIMH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Mood lability is an important transdiagnostic problem that is associated with poor psychosocial function and suicidal thoughts, and is a predictor of mood disorder onset, especially in youth at familial risk. Thus, particularly in youth with a family history of mood disorder, an intervention to target mood lability during a key period of development could improve outcomes. This study will allow us to test neurobehavioral mechanisms of a mindfulness-based intervention to target mood lability in early adolescents at high risk for developing mood disorders. Through this randomized controlled trial, the investigators will better understand how and for whom mindfulness interventions work, which will lead to more targeted interventions to improve emotion regulation during this key developmental period.
CONDITIONS
Official Title
Brain, Emotions, and Mind-Wandering
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Males and females between the ages of 11-14 years
- Parent or full biological sibling with major depressive disorder and/or bipolar I/II disorder
- Elevated mood lability, which is defined as >10 on the Children's Affective Lability Scale (averaging the child and parent score)
You will not qualify if you...
- IQ less than 70 or significant learning disability that makes participation difficult
- Current or previous diagnosis of bipolar disorder, schizophrenia, schizoaffective disorder, or autism spectrum disorder
- Current diagnosis of major depressive disorder
- Contraindications to MRI scanning, including metal in the body such as braces or planned braces within 8 months
- Suicidal or homicidal ideation within the past month
- Changed medications or doses, or started new therapy, within the past two months including psychotropic medications or hormonal contraceptives
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Western Psychiatric Hospital
Pittsburgh, Pennsylvania, United States, 15213
Actively Recruiting
Research Team
D
Danella Hafeman, MD, PhD
CONTACT
A
Ashley Harbaugh, BS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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