Actively Recruiting
Brain Health in Breast Cancer Survivors
Led by Jonsson Comprehensive Cancer Center · Updated on 2026-05-11
120
Participants Needed
1
Research Sites
418 weeks
Total Duration
On this page
Sponsors
J
Jonsson Comprehensive Cancer Center
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Endocrine therapy (ET) is widely used to treat hormone receptor positive breast cancer and prevent recurrence by downregulating estrogen function. However, ETs readily cross the blood brain barrier and interfere with the action of estrogen in the brain. Estrogen supports cognition and menopausal status is closely linked to cognitive health in women. This has raised concern that anti-estrogen ETs may affect cognition and brain health in breast cancer survivors. However, evidence across existing studies is inconsistent and these effects remain poorly understood. The incomplete understanding of the effects of ET are likely due to limitations of earlier studies - namely, the under-appreciation of the role of menopausal status and insensitivity of standard cognitive measures. This research project will address these earlier limitations by specifically comparing ET effects by menopausal status, and using highly sensitive, task-related functional magnetic resonance imaging (fMRI) measures to assess the effects of ET on brain function.
CONDITIONS
Official Title
Brain Health in Breast Cancer Survivors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 35-65
- Fluent in English
- Adequate vision and hearing to complete testing
You will not qualify if you...
- History of major or mild neurocognitive disorder or dementia
- Diagnosis of major neurological condition (e.g., epilepsy, Parkinson's Disease, stroke)
- Diagnosis of a major psychiatric disorder (e.g., bipolar disorder, schizophrenia)
- Untreated or unstable unipolar depression or anxiety
- Prior history of cancer or chemotherapy (for controls, any history)
- History of a learning disorder
- History of head injury with loss of consciousness greater than 20 minutes
- History of salpingo-oophorectomy or hysterectomy
- Having a cardiac pacemaker
- Having an implanted electronic device
- Claustrophobia
- Currently pregnant
- Orbital metal implant or other metallic foreign bodies
- For controls: current use of contraceptive agents interfering with hormonal fluctuation or menstrual pattern determination, or current systemic estrogen replacement therapy
AI-Screening
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Trial Site Locations
Total: 1 location
1
University of California at Los Angeles
Los Angeles, California, United States, 90095
Actively Recruiting
Research Team
K
Kathleen Van Dyk, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
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