Actively Recruiting
Imaging Trial of Biomarkers to Guide Individualized Therapy in Patients With Brain Metastasis Receiving Radiotherapy
Led by University Health Network, Toronto · Updated on 2026-03-05
90
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying patients with brain metastases to see how certain imaging biomarkers can predict responses to radiation treatment. This phase II trial focuses on validating these biomarkers using advanced brain imaging techniques. The study aims to improve understanding of how early changes seen on CT and MRI scans relate to treatment outcomes in these patients. Participants will have CT and MRI scans before starting radiation therapy, and again one week after completing radiotherapy. Another MRI scan will be done during the usual 3-month follow-up visit. These imaging procedures are designed to measure biomarkers that might indicate how well the tumor responds to radiation. Patients will be involved in the study for up to two years, during which time researchers will monitor their scans and clinical status. Outcomes measured include tumor response assessments using established criteria (RANO and RECIST) and progression-free survival. The study also tracks any unexpected or serious side effects related to the treatment over the two-year period.
CONDITIONS
Brief Title
Brain Imaging Biomarkers in Patients With Brain Metastasis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Biopsy proven primary malignancy with brain metastases consistent on imaging
- At least one brain lesion larger than 1 cm without signs of hemorrhage
- Age 18 years or older
- Planned to receive radiation therapy for brain metastases
- Able to understand and willing to sign informed consent
You will not qualify if you...
- Previous whole brain radiotherapy
- Previous radiosurgery to the target brain lesion
- Unable to undergo contrast-enhanced MRI for any reason
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Approximately 2 weeks
Participants undergo CT and MRI scans before and shortly after radiation therapy to measure imaging biomarkers.
2 visits (in-person) within one week before and one week after radiation therapy
Duration - Up to 2 years
Participants are monitored with an MRI scan during their 3-month post-treatment follow-up as part of routine care, and followed for up to 2 years to assess response and progression.
1 MRI scan at 3 months post-treatment plus other routine follow-up visits over 2 years
Trial Site Locations
Total: 1 location
1
University Health Network
Toronto, Ontario, Canada, L4W4C2
Actively Recruiting
Research Team
D
David Shultz, M.D., Ph. D
C
Catherine Coolens, Ph. D
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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