Actively Recruiting
A Brain Imaging Study to Assess the Binding of MSP-2020 to Serotonin 5-HT2A Receptors in Healthy Male Adults
Led by Otsuka Pharmaceutical Development & Commercialization, Inc. · Updated on 2026-02-27
18
Participants Needed
1
Research Sites
56 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is to see how well MSP-2020 attaches to specific targets in the brain called serotonin type 2A receptors (5-HT2AR). This study will also look at how much of the study drug (and its metabolite) is in the blood and how long the study drug stays in the blood, as well as the safety of MSP 2020.
CONDITIONS
Official Title
A Brain Imaging Study to Assess the Binding of MSP-2020 to Serotonin 5-HT2A Receptors in Healthy Male Adults
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Able to stay in the clinical research unit for up to 4 days
- Body mass index (BMI) between 18.0 and 32.0 kg/m2 inclusive
- In good health as determined by medical history, physical and neurological exams, medications review, ECG, echocardiogram, and laboratory tests including HIV, hepatitis B and C screening
You will not qualify if you...
- First-degree relatives with schizophrenia-spectrum, psychotic, or bipolar disorders
- Allergy to tracer [11C]CIMBI-36
- MRI incompatibility due to implants, metal fragments, claustrophobia, or inability to lie still
- Pathological MRI findings preventing participation
- Prior radiation exposure exceeding annual limit within 12 months before first PET scan
- Negative modified Allen test at screening
- Contraindications to radial arterial cannula such as infection or abnormal coagulation
- Clinically significant medical abnormalities affecting safety or drug metabolism
- Alcohol or substance use disorder in the past 24 months or high alcohol intake
- Inability to avoid alcohol from 48 hours before screening until discharge on Day 2
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
HMR Hammersmith Medicines Research Ltd.
London, United Kingdom
Actively Recruiting
Research Team
O
Otsuka Call Center
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
1
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