Actively Recruiting
Brain Imaging Study on Biomarkers for Fibromyalgia
Led by Nova Scotia Health Authority · Updated on 2024-08-22
35
Participants Needed
1
Research Sites
726 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Drugs used for managing Fibromyalgia pain have not proven to be effective and pain continues to cost Canadians $60 billion a year without truly helping those who suffer. The study proposes to investigate the factors related to a person that can enhance or reduce the effectiveness of pain treatments in people suffering with Fibromyalgia pain. Treatment response to painkillers in a person may be related to their brain, social, and psychological makeup. The investigators aim to study these factors to identify and develop feasible and robust indicators based on a person's biological makeup (also called biomarkers). These biomarkers will allow doctors and researchers to predict more accurately which treatment and prevention strategies for a particular disease will work in which groups of people. These measures will offer new opportunities for improving treatment such as by tailoring treatment to meet the specific needs of each patient based on his/her biological and psychological makeup. Towards the specific aim, data will first be collected in several experimental domains for studying treatment expectations (cognitive, psychosocial, brain-related). These 'experimental' data will be compared between Fibromyalgia (FM) and healthy participants to yield new understanding of the factors that govern treatment response. At the end of experimental data collection, the investigators will collect data in the 'clinical' domain. Hence, at the end of the experimental sessions, a subset of FM participants will receive a mock drug (placebo disguised as an approved pain treatment) and another subset will provide pain ratings only and hence serve as a waiting list control for the placebo trial. Data will be studied in steps to understand factors that mediate treatment outcomes and finally the investigators will use advanced computational tools used for big data analysis and aim to identify factors that can be used as biomarkers and precision medicine tools.
CONDITIONS
Official Title
Brain Imaging Study on Biomarkers for Fibromyalgia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 75 years
- Right-handed
- For chronic pain participants: chronic low back pain lasting more than 6 months
- For chronic pain participants: average clinical pain at least 4 out of 10 in the two weeks before enrollment
- Comfortable reading and writing English to complete questionnaires and tasks
- For healthy participants: age between 18 and 75 years
- For healthy participants: right-handed
- For healthy participants: comfortable reading and writing English to complete questionnaires and tasks
You will not qualify if you...
- History of cardiac, respiratory, or nervous system diseases that may interfere with participation or increase risk, such as asthma or claustrophobia
- Any contraindications to MRI scanning, including cardiac pacemaker, metal implants, fear of closed spaces, or pregnancy
- For healthy participants: any acute or chronic pain
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Nova Scotia Health Authority
Halifax, Nova Scotia, Canada, B3h1V7
Actively Recruiting
Research Team
J
Javeria A Hashmi, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
HEALTH_SERVICES_RESEARCH
Number of Arms
3
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