Actively Recruiting
Brain-lung Interactions in Adults Receiving High-flow Humidified Oxygen for Acute Hypoxemic Respiratory Failure
Led by Assistance Publique - Hôpitaux de Paris · Updated on 2026-05-01
25
Participants Needed
2
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Acute hypoxemic de novo respiratory failure (AHRF) is a common reason for admission to intensive care units, often caused by community-acquired pneumonia. This condition sometimes requires high-flow nasal cannula (HFNC) oxygen therapy to avoid intubation, but about 40% of patients still need to be intubated. Researchers aim to study the interaction between the brain and lungs in adult patients with AHRF who start HFNC treatment, using advanced brain activity and oxygenation measurements previously tested only in intubated patients. The study involves observing adult patients admitted to intensive care with AHRF who are treated with HFNC as decided by their physician. Before and one hour after starting HFNC, researchers will record brain activity using electroencephalogram (EEG), near-infrared spectroscopy (NIRS), and electromyogram (EMG) of the scalene muscles. These recordings will measure brain wave activity in various regions, connectivity between brain areas, breathing-related brain signals, and muscle activity, to explore brain-lung interactions. Participants will undergo two 10-minute recording sessions including continuous EEG, NIRS, and EMG monitoring, plus intensive care data collection every minute. Researchers will compare these measures before and after HFNC initiation and between patients who require intubation and those who do not. The primary outcome is the change in gamma frequency brain activity in the right prefrontal cortex. The study will monitor participants during their intensive care stay, with no additional long-term follow-up mentioned.
CONDITIONS
Brief Title
Brain-lung Interaction During Acute Respiratory Failure
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Admitted to intensive care within the last 48 hours
- De novo acute hypoxemic respiratory failure indicated for high-flow nasal cannula (HFNC) treatment, defined by:
- Tachypnea over 25 breaths per minute or labored breathing
- PaO2/FiO2 ratio of 200 mmHg or less
- Unilateral or bilateral alveolar opacities on chest X-ray
- Decision by the attending physician to start HFNC treatment
- Patient or next of kin did not refuse participation (written consent waived)
You will not qualify if you...
- Exacerbation of an existing chronic respiratory disease
- Acute cardiogenic pulmonary edema requiring non-invasive ventilation (NIV)
- High carbon dioxide levels (hypercapnia above 45 mmHg) indicating NIV
- Glasgow Coma Scale score below 13
- Imminent need for intubation
- Central neurological disease likely to affect EEG results
- Pregnancy or breastfeeding
- Lack of health insurance coverage
- Patient under legal protection
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Approximately 1 hour
Participants undergo two 10-minute recordings including EEG, NIRS, and EMG data collection before and one hour after initiation of high-flow nasal cannulae (HFNC). Intensive care monitoring variables are also collected during recordings.
1 visit (in-person)
Duration - Up to hospital discharge or as determined by clinical course
Participants are observed for outcomes related to brain-lung interactions and potential need for intubation following HFNC treatment initiation.
Additional assessments may occur depending on clinical status
Trial Site Locations
Total: 2 locations
1
Médecine Intensive - Réanimation, Hôpital Pitié Salpêtrière
Paris, France, 75013
Actively Recruiting
2
Service de Médecine Intensive et Réanimation, Hôpital Pitié Salpêtrière
Paris, France
Not Yet Recruiting
Research Team
A
Alexandre Demoule
M
Martin Dres
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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