Actively Recruiting
Brain Mechanisms of Social Perception in Parkinson's Disease
Led by Hospices Civils de Lyon · Updated on 2025-07-22
83
Participants Needed
1
Research Sites
89 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Social cognition is a complex process that enables humans to interpret social information and behave appropriately in a social environment. Social cognition can be impaired in Parkinson's disease patients, worsening quality of life and relationships with those around them, even at an early stage. These alterations are manifested in particular by impairments of the recognition of facial emotions and body movements, involving the motor system. The aim of this study is to understand the brain mechanisms associated with impaired social perception in people with Parkinson's disease using functional MRI and a behavioural task for the perception of social interaction scenes depicted by "Point Light Display" (PLD).This study will investigate the effect of dopaminergic modulation on the networks associated with the perception of movement and mirror system, the observation of action (parietal cortex, superior temporal sulcus), and those associated with the mentalization of others' cognitive or emotional states (prefrontal cortex and limbic system). The study is thus divided into 2 stages. * Stage 1 "preliminary": Preliminary validation of the experimental task * Stage 2 "imagery": Assessment of brain activity (BOLD signal) related to social perception in imaging
CONDITIONS
Official Title
Brain Mechanisms of Social Perception in Parkinson's Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female between 30 and 75 years of age
- Provided written informed consent to participate
- Affiliated with a social security system or equivalent
- Diagnosed with Parkinson's disease according to MDS-UPDRS criteria for at least 3 years and receiving dopaminergic treatment (e.g., LEVODOPA, CARBIDOPA, PRAMIPEXOLE, etc.) (patients only)
- Effective contraception for women of childbearing age or post-menopausal women (patients and healthy volunteers in stage 2 "imaging" only)
- Require dopa testing as part of routine care (patients in stage 2 "imaging" only)
- No disabling cognitive impairment (MoCA score ≥ 26)
- No diagnosis of chronic disease associated with disability (healthy volunteers only)
You will not qualify if you...
- Contraindications to MRI, including pacemaker not approved for 3 Tesla MRI, intracerebral or intraocular ferromagnetic or magnetizable material, non-removable ferromagnetic material in the head, or claustrophobia (patients and healthy volunteers in stage 2 "imaging" only)
- History of head trauma with loss of consciousness over 30 minutes (patients and healthy volunteers in stage 2 "imaging" only)
- Decline to be informed if an abnormality is found on MRI (patients and healthy volunteers in stage 2 "imaging" only)
- Tremor or disabling dyskinesias preventing MRI (patients in stage 2 only)
- Exceeded allowed annual compensation for research participation (healthy volunteers only)
- Pregnant, parturient, or breastfeeding women
- Persons deprived of liberty by judicial or administrative decision
- Persons under psychiatric care
- Persons admitted to a health or social institution for purposes other than research
- Adults under legal protection (guardianship, curatorship)
- Participation in other interventional research with exclusion periods still active at pre-inclusion
AI-Screening
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Trial Site Locations
Total: 1 location
1
Service de neurologie - troubles du mouvement et pathologies neuromusculaires, Hôpital neurologique Pierre Wertheimer/GHE
Bron, France, 69677
Actively Recruiting
Research Team
S
Stéphane PRANGE, MD, PhD
CONTACT
E
Elise METEREAU
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
4
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