Actively Recruiting
Brain Mechanisms Supporting Cannabis-induced Pain Relief
Led by University of California, San Diego · Updated on 2024-01-08
100
Participants Needed
2
Research Sites
305 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The American Academy of Pain Medicine has labeled pain as a "silent epidemic" due to its staggering costs to society (over $500 billion/year) and widespread prevalence (affects over 100 million Americans). Thus, it is imperative to test and validate cost-effective pain therapies. To this extent, cannabis is characterized as one of the most promising therapies to treat a wide spectrum of pain conditions. However, the clinical applicability of cannabis-based pain therapies has been limited due to lacking mechanistic characterization in human-focused studies. Of critical importance, the neural mechanisms supporting cannabis induced pain relief remain unknown. The primary objective of the proposed pilot study is to identify the brain mechanisms supporting the direct alleviation of acutely evoked pain through vaporized cannabis.
CONDITIONS
Official Title
Brain Mechanisms Supporting Cannabis-induced Pain Relief
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Between 21 and 65 years old
- No previous medical history such as cardiac or pulmonary disease
- Not currently using any cannabis
- Previous history of cannabis use within the past two years
- Cannabis-free for at least 30 days before participation
- Not taking opioids
- If female and of childbearing potential, not pregnant or nursing
- No sensory or motor deficits that prevent participation in pain procedures
- No lifetime history of cannabis dependence
- No history of schizophrenia, bipolar disorder, generalized anxiety or panic disorder, or previous psychosis with or intolerance to cannabinoids
- Agree not to use cannabis outside of the study during participation
- Agree not to use opioids or barbiturates during participation
- Agree not to drive a motor vehicle within 4 hours after inhaled cannabis use during participation
You will not qualify if you...
- Current or past history of cannabis, alcohol, or opioid abuse
- Active pulmonary disease
- Allergy or past negative effects from cannabis
- Positive urine drug test for THC, barbiturates, opioids, oxycodone, or methadone before the first study session
- Pregnancy
- Breastfeeding
- Prisoner status
- Known cognitive impairment
- Institutionalized
- Claustrophobia
- MRI contraindications
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
Altman Clinical and Translational Research Institute
La Jolla, California, United States, 92093
Actively Recruiting
2
University of California, San Diego
San Diego, California, United States, 92093
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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