Study of How Vaporized Cannabis Affects Brain Activity and Pain Relief in Adults with Chronic Low Back Pain

What this Trial Is About

Chronic low back pain is a widespread and disabling condition affecting many adults, with limited effective treatments available. Researchers are studying how inhaled cannabis impacts brain activity and reduces pain in adults with chronic low back pain. This early-phase study compares cannabis containing tetrahydrocannabinol THC to a placebo cannabis with no THC to better understand cannabiss effects on pain and brain function. Participants will inhale 400 mg of vaporized cannabis containing 5.1% THC or placebo cannabis with less than 0.1% THC using a vaporization device under supervision. The study involves one visit during which brain imaging fMRI, heat pain testing, and leg raise assessments are performed before and after cannabis administration. Researchers will measure pain responses and brain activity changes to evaluate cannabiss impact. During the single study session, participants will complete screening, questionnaires, and pain testing using heat stimulation on the calf. They will rate pain intensity and unpleasantness, and a straight leg raise will assess low back and leg pain. Researchers will monitor cerebral blood flow and self-reported pain, mood, sleep, stress, and cannabis-related effects using standardized questionnaires to provide a comprehensive understanding of cannabiss influence on chronic low back pain.

Brain Mechanisms Supporting Cannabis-induced Pain Relief