Actively Recruiting
Brain NAD in Alzheimer's Disease
Led by Florida Atlantic University · Updated on 2026-03-24
20
Participants Needed
1
Research Sites
62 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this observational study is to learn about the levels of nicotinamide adenine dinucleotide (NAD) in the brains of people with Alzheimer's disease. The study aims to determine if brain NAD levels are lower in people with Alzheimer's disease compared with people of the same age group who do not have Alzheimer's disease. Participants with or without Alzheimer's disease will have a brain imaging session where NAD will be measured using magnetic resonance spectroscopy (MRS). Eight months later, they will have a second, similar, brain imaging session.
CONDITIONS
Official Title
Brain NAD in Alzheimer's Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants are able to come to the Florida Atlantic University Clinical Research Unit, are verbal and ambulatory.
- Age 65 to 80 years.
- People with Alzheimer's disease: diagnosis confirmed by a physician with clinical diagnosis and either positive amyloid PET scan or FDA-approved positive CSF or blood test.
You will not qualify if you...
- Under 65 years or over 80 years of age.
- Advanced dementia requiring sedation for MRI.
- Receiving anti-amyloid intravenous treatments Leqembi or Kinsula.
- Having MRI-incompatible pacemaker or hardware.
- History of seizures.
- Working at night.
- Having cancer or diagnosed with cancer within the last 5 years (excluding superficial squamous or basal cell cancer).
- People without Alzheimer's disease with MoCA test result lower than 26.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
FAU Clinical Research Unit
Boca Raton, Florida, United States, 33431
Actively Recruiting
Research Team
F
FAU Clinical Research Unit Central Contact
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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