Brain Network Changes in Adults With Obsessive-Compulsive Disorder Predicting Responses to Fluoxetine Treatment in a Randomized, Double-Blind Study

What this Trial Is About

Researchers are investigating brain network changes in adults with obsessive-compulsive disorder OCD to find predictors and connections related to responses to fluoxetine, a common medication for OCD. The study includes healthy adults as a comparison group and uses advanced brain imaging techniques to better understand OCD symptoms and treatment effects. The research aims to identify brain markers linked with OCD symptoms and how patients respond to fluoxetine treatment. The study involves two main groups healthy adults who will have one brain scan at the start without treatment, and adults with OCD who are not currently on medication. Those with OCD will be randomly assigned in a double-blind manner to either start fluoxetine immediately or after a 6-week placebo period. Brain scans will be done at the beginning and during treatment to observe changes. Analyses will explore brain connectivity related to OCD symptoms and treatment response. Participants will undergo clinical assessments and functional MRI scans to monitor brain activity. Those with OCD will be evaluated over 18 weeks, including checking symptom severity and other related measures such as depression and anxiety. The study will track changes in OCD symptoms as the primary outcome, with several secondary measures also assessed. Participants will be closely monitored to ensure safety and study adherence throughout the trial.

Brain Network Changes Accompanying and Predicting Responses to Pharmacotherapy in OCD