Actively Recruiting

Phase Not Applicable
Age: 18Years - 65Years
All Genders
NCT06942559

Brain-Oscillation Synchronized Stimulation of the DMPFC

Led by Centre for Addiction and Mental Health · Updated on 2025-04-24

48

Participants Needed

1

Research Sites

204 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

This trial aims to obtain initial evidence about the clinical efficacy and modulation of neurophysiological markers in obsessive compulsive disorder (OCD) using personalized (i.e., electroencephalography (EEG)-triggered) repetitive transcranial magnetic stimulation (rTMS) as compared to non-personalized (i.e., non-EEG triggered), standard rTMS applied to the dorsomedial prefrontal cortex.

CONDITIONS

Official Title

Brain-Oscillation Synchronized Stimulation of the DMPFC

Who Can Participate

Age: 18Years - 65Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Be between 18 and 65 years old
  • Have OCD as the primary disorder confirmed by a MINI diagnosis, with treatment resistance after at least one cognitive-behavioural therapy course or one SSRI trial
  • Not meet criteria for substance use disorder except nicotine and caffeine
  • Have a Yale-Brown Obsessive Compulsive Scale (Y-BOCS) score greater than 20
  • Be fluent in English (spoken, written, reading)
  • Have had no increase or start of psychotropic medication in the 4 weeks before screening
  • Be capable of giving informed consent
  • Sign and date the informed consent form
  • Willing to follow all study procedures
Not Eligible

You will not qualify if you...

  • Have any contraindications to TMS per the TASS questionnaire
  • Have a history of medical or neurological disorders affecting the central nervous system (e.g., brain injury, stroke, Parkinson's disease)
  • Be currently pregnant or breastfeeding
  • Have a history of seizures
  • Have metal implants or dentures
  • Have serious or unstable medical conditions needing immediate care (e.g., severe cardiac disease)
  • Have cardiac pacemaker, cochlear implants, implanted electronic devices, non-electronic metallic implants, or other rTMS contraindications
  • Take more than 2mg lorazepam or equivalent benzodiazepine, or any anticonvulsant medication
  • Meet criteria for Alcohol Use Disorder

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Centre for Addiction and Mental Health

Toronto, Ontario, Canada, M6J 1H1

Actively Recruiting

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Research Team

B

Brigitte Zrenner, MD

CONTACT

N

Nina E. Bahl, MSc

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

DOUBLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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