Personalized EEG-Triggered vs Standard rTMS Treatment for Adults With Obsessive Compulsive Disorder

What this Trial Is About

Researchers are studying obsessive compulsive disorder OCD to compare two types of repetitive transcranial magnetic stimulation rTMS treatments. They aim to see how personalized, EEG-triggered rTMS affects OCD symptoms and brain activity compared to non-personalized, standard rTMS. This study follows a prospective, randomized, single-blind design at the Centre for Addiction and Mental Health and focuses on clinical effects and changes in brain signals related to OCD. Participants receive treatment five days a week for six weeks, totaling 30 sessions. Both groups get rTMS targeting the dorsomedial prefrontal cortex with the same coil, intensity, and pulse number. The personalized group receives EEG-triggered rTMS pulses synchronized to brain waves, while the other group gets standard non-EEG triggered rTMS at high frequency. Each session lasts about 17 minutes. Throughout the study, researchers measure OCD symptoms using the Yale-Brown Obsessive Compulsive Scale Y-BOCS, the Obsessive Compulsive Inventory - Revised OCI-R, and the Clinical Global Impressions - Improvement CGI-I scale. They also track changes in EEG brain wave patterns. Assessments occur from screening through one week after treatment ends. Participants safety and adherence are monitored during this time, with the total involvement lasting about seven weeks.

Brain-Oscillation Synchronized Stimulation of the DMPFC