Impact of Weight Loss on Alzheimers Risk in Adults with Down Syndrome A Study of Diet and Brain Health Over 12 Months

What this Trial Is About

Researchers are investigating whether weight loss or changes in diet can help prevent or delay the development of Alzheimers disease in adults with Down syndrome who do not have dementia. This study compares the effects of a reduced calorie diet and monthly behavioral counseling with general health education sessions delivered remotely. The goal is to better understand how lifestyle changes may influence Alzheimers risk in this specific population. Participants will be randomly assigned to either a weight loss group or a general health education control group. The weight loss group will follow a reduced calorie diet focusing on frozen meals and increased fruits and vegetables linked to brain health, attend monthly remote education sessions, and self-monitor their diet and weight using web-based applications. The control group will participate in monthly remote sessions about general health topics. The study lasts 12 months. All participants will visit the University of Kansas Medical Center three times during the year for blood draws, cognitive tests, MRI brain scans, and assessments of height, weight, and dietary intake. Researchers will measure blood markers related to Alzheimers disease, body weight, diet quality, brain volume, and cognitive function at baseline, 6 months, and 12 months. This allows comprehensive monitoring of health and brain outcomes throughout the study.

Brain Outcomes With Lifestyle Change in Down Syndrome