Using Theta Burst Brain Stimulation to Target Hippocampal Function in Schizophrenia A Study of Invasive and Noninvasive Brain Stimulation Techniques

What this Trial Is About

Researchers are studying schizophrenia, a condition marked by delusions, hallucinations, and cognitive challenges that causes significant disability. The study focuses on how brain activity in the hippocampus, a key brain region, may be influenced by non-invasive brain stimulation techniques like transcranial magnetic stimulation TMS. This research aims to better understand hippocampal function in schizophrenia and explore new ways to use brain stimulation as a potential treatment. The study compares different brain stimulation methods using intracranial electrodes and TMS to deliver theta burst stimulation TBS to the hippocampus. Participants will receive either active TBS via direct electrical stimulation or TMS, or sham versions of these stimulations where no real current or brain stimulation is applied. These interventions will help researchers observe the effects of targeted brain stimulation on hippocampal-cortical rhythms. Participants will undergo sessions lasting about 45 minutes where brain activity is recorded using intracranial and scalp EEGs before and after stimulation. Researchers will measure changes in EEG power triggered by TBS and electrical stimulation to assess brain response. The study includes randomized assignment to treatment groups and single masking, with follow-up assessments to monitor outcomes and safety throughout the trial.

Brain Stimulation to the Hippocampus in Schizophrenia