Actively Recruiting

Phase Not Applicable
Age: 21Years - 39Years
FEMALE
Healthy Volunteers
NCT06126627

Brain and Voice Signatures in Teachers

Led by University Hospital, Bonn · Updated on 2025-08-27

100

Participants Needed

1

Research Sites

156 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Primary muscle tension dysphonia voice disorder with symptoms of vocal strain and vocal fatigue is common and can have a significant negative impact on quality of Life. Yet, primary muscle tension dysphonia's causes are unknown precluding precise diagnostic classification. Stress and personality are thought to play a role and thus, the project aims to determine the practical and clinical effect of stress on the control of voice and speech in the brain. Participants are female early career teachers and student teachers with symptoms of vocal fatigue, as well as control participants without vocal fatigue, who perform speech tasks on two different occasions. Neural (imaging of brain), psychobiological (saliva, personality), and voice and speech (muscle activity of voice muscles on the neck with surface sensors, audio recordings) data will compare reactivity patterns of teachers who are stressresponders with those who are nonresponders as well as control participants. The central hypothesis is that voice box stress responders have heightened emotion-motor activations involving the emotional voice production pathway, which correlate with changes in voice muscle activity in the anterior neck. The results will provide fundamentally missing data in our understanding of the role of stress in vocal complaints and will yield new insights about the neural underpinnings of primary muscle tension dysphonia. The study findings will have a significant impact on how clinicians identify so-called laryngoresponders to help them prevent voice disorders.

CONDITIONS

Official Title

Brain and Voice Signatures in Teachers

Who Can Participate

Age: 21Years - 39Years
FEMALE
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Teachers (max. 10 years full-time) or student teachers in good health between 21 and 39 years with symptoms of vocal fatigue
  • Control participants in good health between 21 and 39 years without symptoms of vocal fatigue
Not Eligible

You will not qualify if you...

  • Lefthandedness
  • Smoking (past 5 years)
  • Known changes of the vocal folds such as nodules, paralysis, surgeries on the larynx or thyroid, or current organic or neurological vocal fold changes
  • History of voice therapy
  • Hoarseness
  • Respiratory illness, allergies (respiratory, silver), reflux or asthma at time of participation
  • Hearing disorder or use of hearing aids
  • Psychological, neurological, or endocrinological disorders
  • Use of psychotropic or steroid medications
  • Body mass index greater than 30
  • Contraindications for MRI such as metal parts in or on the body (e.g., dental prostheses, braces, screws, prostheses, piercings, large tattoos)
  • Nearsightedness worse than -5 diopters if only glasses are worn
  • Claustrophobia
  • Pregnancy

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

University Hospital Bonn

Bonn, Germany, 53127

Actively Recruiting

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Research Team

M

Maria Dietrich, PhD

CONTACT

L

Lisa Sindermann, PhD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NON_RANDOMIZED

Model

PARALLEL

Primary Purpose

BASIC_SCIENCE

Number of Arms

2

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Brain and Voice Signatures in Teachers | DecenTrialz