Actively Recruiting
Breaking Sitting with High-intensity Interval Training for Brain Health
Led by University of Illinois at Urbana-Champaign · Updated on 2025-02-07
54
Participants Needed
1
Research Sites
64 weeks
Total Duration
On this page
Sponsors
U
University of Illinois at Urbana-Champaign
Lead Sponsor
N
Northeastern University
Collaborating Sponsor
AI-Summary
What this Trial Is About
This trial will examine whether interrupting 3.5 hours of sitting every 30 min with 6 min high intensity interval training (HIIT) breaks compared to light intensity interval training (LIIT) will improve brain health in cognitively normal older adults. This trial will test the feasibility of HIIT breaks to sitting. It will also address several important but unanswered questions: (1) Does interrupting sitting with short HIIT breaks improve frontoparietal function? (2) Can interrupting sitting with HIIT breaks improve cognitive functions?
CONDITIONS
Official Title
Breaking Sitting with High-intensity Interval Training for Brain Health
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 40 and 75 years
- Body mass index (BMI) less than 40 kg/m2
- Sitting for 6 or more hours per day based on a survey
- Physically inactive with less than 300 minutes of moderate activity per week
- Able to exercise vigorously as determined by the Physical Activity Readiness Questionnaire (PARQ+)
- Medical clearance for maximal exercise and high-intensity interval training from a physician
- Normal or controlled blood pressure
- Intelligence quotient (IQ) of 85 or higher
- Fasting plasma glucose below 126 mg/dL
- Good or corrected vision and hearing
- Right-handed
- No significant abnormalities on electrocardiogram during maximal exercise test
- No signs or symptoms of underlying cardiovascular disease based on maximal exercise test
- No indications to stop maximal exercise test early according to ACSM guidelines
- Concussion only if more than 12 months before screening
- History of cancer in full remission for at least 12 months with no chemotherapy, confirmed by physician or oncologist
You will not qualify if you...
- Physical disability or musculoskeletal disease preventing vigorous exercise
- Learning disabilities
- Cognitive impairment with a MoCA score below 26
- Type 1 or 2 diabetes
- Neurological conditions such as multiple sclerosis, Parkinson's disease, dementia, or mild cognitive impairment
- Color blindness
- Brain injury including traumatic brain injury, stroke, or recent concussion
- Migraine headaches
- Health conditions that may worsen with exercise
- History of heart disease
- Uncontrolled high cholesterol
- Signs or symptoms of cardiovascular disease
- Chronic pulmonary diseases including emphysema, pulmonary embolus, or asthma
- History of renal disease or seizures
- Neuropsychiatric disorders
- Osteoporosis or severe arthritis affecting ability to exercise
- Severe back problems
- Thyroid disorder not controlled by medication
- Polyneuropathy
- Sleep disorders
- Acquired immunodeficiency syndrome (AIDS)
- Hepatitis C
- History of long COVID-19
- History of cancer not in full remission or recent chemotherapy
- Current or past smoking within 12 months
- Recent corticosteroid, opioid, or anabolic androgen use
- Serious illness or hospitalization in past 6 months
- Use of medications affecting the central nervous system (except anxiolytics)
- Participation in another trial that affects exercise ability or cognitive function
AI-Screening
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Trial Site Locations
Total: 1 location
1
University of Illinois at Urbana-Champaign
Urbana, Illinois, United States, 61801
Actively Recruiting
Research Team
D
Dominika M Pindus, Ph.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
PREVENTION
Number of Arms
2
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