Study Comparing Frequent Short Walks Versus One Daily Walk to Improve Blood Sugar Control in Adults at Risk for Type 2 Diabetes

What this Trial Is About

Researchers are investigating how breaking up long periods of sitting with short bouts of physical activity affects blood sugar control in adults at risk of developing type 2 diabetes. The study focuses on adults with prediabetes, aiming to see if interrupting sedentary time with frequent activity improves glucose levels more than a single continuous exercise session. This research addresses gaps about the lasting effects and underlying mechanisms of such activity patterns in this population. Participants will be randomly assigned to one of two groups for a 3-month period. One group BREAK will do 5-minute brisk walking sessions every hour for 9 hours a day, 5 days a week. The other group ONE will perform a single 45-minute brisk walk daily, 5 days a week. Both interventions match the total active time but differ in how activity is spread across the day. During the study, participants will wear activity monitors and follow controlled diets before certain clinic visits. Researchers will measure blood glucose levels using fasting tests and 2-hour oral glucose tolerance tests, along with other metabolic markers and muscle protein content. Outcomes will be assessed before, during, and after the intervention periods, with monitoring of exercise adherence, safety, and other health parameters throughout the trial.

Breaking up Sedentary Time to Improve Glucose Control in a Population at Risk for Developing Type 2 Diabetes