Actively Recruiting
Breath Analysis for the Detection of Invasive Fungal Infections
Led by University of Zurich · Updated on 2025-04-10
130
Participants Needed
1
Research Sites
166 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Patients with leukemia and concomitant neutropenia are at high risk of developing invasive fungal infections (IFI) that are associated with high morbidity and mortality. As these patients typically have severe thrombocytopenia, direct diagnostic sampling with invasive procedures is often not possible due to the high peri-interventional risk. Therefore, the presumptive diagnosis of IFI is primarily based on compatible lung findings on computed tomography and serologic detection of fungal cell wall components, which, however, have limited sensitivity and specificity. With the present study, the investigators aim to determine a set of specific volatile biomarkers in leukemia patients with proven or probable IFI using secondary electrospray ionization high-resolution mass spectrometry (SESI-HRMS).
CONDITIONS
Official Title
Breath Analysis for the Detection of Invasive Fungal Infections
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of acute leukemia
- Planned chemotherapy with hospitalization lasting 2 weeks or longer
- Neutropenia (less than 500/µl) present at inclusion or expected neutropenia (less than 500/µl) for more than 7 days due to planned chemotherapy
You will not qualify if you...
- Inability to follow instructions for breath analysis
- Anatomical abnormalities that prevent use of a mouthpiece for breath analysis
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University Hospital of Zurich
Zurich, Canton of Zurich, Switzerland, 8091
Actively Recruiting
Research Team
J
Jeremy Deuel, PD Dr.
CONTACT
K
Kevin Hofer, Dr.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
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