Actively Recruiting
Breathing With Amyotrophic Lateral Sclerosis
Led by University Hospital, Toulouse · Updated on 2026-05-12
36
Participants Needed
1
Research Sites
174 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The study aims to evaluate the effect of mechanical insufflator-exsufflator on the respiratory functions of Amyotrophic Lateral Sclerosis (ALS) patients evaluated via peak expiratory flow on cough (PEFC) measurements. The evolution of their PEFC is monitored to see if the curative management can have a positive impact on the latter.
CONDITIONS
Official Title
Breathing With Amyotrophic Lateral Sclerosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Confirmed ALS categorized as probable or certain according to the revised Awaji-Shima criteria
- ALS of spinal, bulbar or respiratory forms
- Peak flow measure between 160 and 255 L/min
- No more than 10 sessions of MIE treatment in the past year
- Ability to use the MIE device or have a caregiver who can assist
- Receiving physiotherapy treatment at least twice a week
You will not qualify if you...
- Psychiatric or cognitive disorders that prevent study participation
- Contraindications to MIE use, such as pneumothorax
- Insufficient French language skills to understand the study and complete questionnaires
- Current or past participation in another respiratory research or care program
- Emergency need for MIE setup within less than one week
- During study: serious contraindications to MIE use (e.g., rib fracture)
- Physiotherapist refusal to participate in the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
SLA Center - Purpan University Hospital Toulouse, FRANCE
Toulouse, Occitanie, France, 31000
Actively Recruiting
Research Team
T
Thierry LAGARDE, PT
CONTACT
F
Floriane LLORENS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
1
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