Actively Recruiting
Breathomics in the Diagnosis and Prediction of Radiotherapy-Induced Oropharyngeal Mucositis in Head and Neck Tumors
Led by Nanfang Hospital, Southern Medical University · Updated on 2025-01-10
375
Participants Needed
1
Research Sites
72 weeks
Total Duration
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AI-Summary
What this Trial Is About
Radiotherapy-Induced Oropharyngeal Mucositis (RIOM) is one of the most distressing side effects for patients with head and neck tumors during radiotherapy, requiring clinical physicians to manage it according to the severity of mucositis to alleviate symptoms and improve quality of life. However, traditional diagnosis of RIOM overly relies on subjective evaluation, lacks early sensitivity, and existing biomarker diagnostic methods suffer from insufficient efficacy, invasiveness, and inconsistent results. This study aims to explore the diagnostic and predictive value of exhaled breathomics in RIOM of head and neck tumors. By collecting exhaled breath samples from head and neck tumor patients undergoing radiotherapy and analyzing volatile organic compounds (VOCs) using breath detection technology, we aim to develop and validate a non-invasive diagnostic and predictive model based on exhaled breathomics. The study will identify specific VOCs as potential biomarkers, providing new tools for early diagnosis, timely prediction, and personalized treatment of RIOM.
CONDITIONS
Official Title
Breathomics in the Diagnosis and Prediction of Radiotherapy-Induced Oropharyngeal Mucositis in Head and Neck Tumors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Voluntarily sign informed consent
- Age 18 to 75 years
- Histologically confirmed head and neck tumors
- Receiving radiotherapy or chemoradiotherapy
- ECOG Performance Status Score of 0, 1, or 2
You will not qualify if you...
- Lung diseases such as lung cancer, tuberculosis, or lung infections
- Inhalation anesthesia within the past 3 months
- Use of inhalation medication within the past 3 months
- Postoperative laryngeal cancer
- Serious uncontrolled medical conditions like unstable heart disease needing treatment
- Poorly controlled diabetes with fasting blood glucose greater than 1.5 times the upper limit of normal
- Investigator judges participation as inappropriate
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Nanfang hospital, Southern medical university
Guangzhou, Guangdong, China, 510515
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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