Actively Recruiting
Brentuximab Vedotin in Early Stage Hodgkin Lymphoma
Led by University College, London · Updated on 2026-03-30
1042
Participants Needed
70
Research Sites
541 weeks
Total Duration
On this page
Sponsors
U
University College, London
Lead Sponsor
T
Takeda
Collaborating Sponsor
AI-Summary
What this Trial Is About
RADAR is a multicentre, international, randomised, open-label phase III clinical trial composed of 2 trials running in parallel. Trial 1 will be led and sponsored by University College London (UCL) and conducted in Europe and Australia/New Zealand. Trial 2 will be led by the Canadian Cancer Trials Group (CCTG) and conducted in North America, with CCTG the regulatory sponsor in Canada, and University of Miami the regulatory sponsor and IND holder in the US. Datasets from Trial 1 and Trial 2 will be combined to achieve the total sample size. Data analysis will be performed by UCL and therefore UCL is responsible for the clinicaltrials.gov entry. Eligible patients will be randomised to receive either ABVD or A2VD chemotherapy. An interim PET-CT scan will be performed after 2 cycles of treatment, which will be used to adapt subsequent treatment. Patients will receive a total of 3-4 cycles of chemotherapy and may also receive involved site radiotherapy as consolidation. Patients will be followed up for a minimum of 5 years after treatment.
CONDITIONS
Official Title
Brentuximab Vedotin in Early Stage Hodgkin Lymphoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Males and females aged 16-69 years (inclusive) (age range is 18-69 in US and EU)
- Histologically confirmed classical Hodgkin lymphoma
- Stage I or II supradiaphragmatic disease without mediastinal bulk disease or B symptoms
- Bulky disease at other sites and single extranodal site (stage I) or contiguous nodal extension (stage II) allowed
- ECOG performance status 0-2
- No previous treatment for Hodgkin lymphoma
- Fit to receive anthracycline-based chemotherapy with left ventricular ejection fraction 50% if history of heart disease or hypertension
- Creatinine clearance >40 ml/min
- Total bilirubin <1.5 x upper limit of normal unless due to disease or Gilbert's syndrome
- ALT or AST <2 x upper limit of normal
- Adequate bone marrow function with neutrophils 1.0x10^9/l and platelets 100x10^9/l
- Haemoglobin 8g/dL
- Willing and able to comply with protocol requirements including contraceptive advice
- Written informed consent
You will not qualify if you...
- Previous treatment for Hodgkin lymphoma except short courses of oral corticosteroids (up to 7 days)
- Infradiaphragmatic disease
- Nodular lymphocyte predominant Hodgkin lymphoma
- Absence of FDG-avid lesions on baseline PET scan
- Age 70 years or over or below 16 years
- Other cancer diagnosed within last 5 years except completely excised carcinoma in situ or basal/squamous cell skin carcinoma
- Recurrent or persistent other cancer within last 5 years
- Pre-existing grade 1 sensory or motor neuropathy
- History or current progressive multi-focal leukoencephalopathy or other chronic brain condition
- Symptomatic neurologic disease affecting daily living or requiring medication
- Infection with HIV, hepatitis C, or active hepatitis B
- Active systemic infection requiring treatment within 2 weeks prior to treatment
- Recent treatment with other investigational agents within 4 weeks
- Pregnant or breastfeeding women
- Known hypersensitivity to recombinant or murine proteins or any drug components
- Known cardiovascular or respiratory conditions precluding anthracycline or bleomycin use
- Other significant medical or psychiatric conditions making treatment hazardous
AI-Screening
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Trial Site Locations
Total: 70 locations
1
Stanford University - (Stanford Cancer Institute)
Stanford, California, United States, 94305
Actively Recruiting
2
University of Miami School of Medicine
Miami, Florida, United States, 33136
Actively Recruiting
3
Memorial Sloan Kettering Cancer Center
New York, New York, United States, 10065
Actively Recruiting
4
Royal North Shore Hospital
Saint Leonards, New South Wales, Australia, 2065
Actively Recruiting
5
Townsville University Hospital
Townsville, Queensland, Australia, QLD 4814
Actively Recruiting
6
Royal Adelaide Hospital
Adelaide, Australia, 5000
Actively Recruiting
7
Box Hill Hospital
Box Hill, Australia, VIC 3128
Actively Recruiting
8
Royal Brisbane and Women's Hospital
Brisbane, Australia, QLD 4006
Actively Recruiting
9
Royal Darwin Hospital
Darwin, Australia, NT 0810
Actively Recruiting
10
Liverpool Hospital
Liverpool, Australia
Actively Recruiting
11
Sunshine Hospital (Western Health)
Melbourne, Australia, VIC 3021
Actively Recruiting
12
Concord Repatriation General Hospital
Sydney, Australia, NSW 2139
Actively Recruiting
13
St George Hospital
Sydney, Australia, NSW 2217
Actively Recruiting
14
AZ Delta Campus Rumbeke
Roeselare, West Flanders, Belgium, Deltalaan 1, 8800
Actively Recruiting
15
Universitair Ziekenhuis Antwerpen
Antwerp, Belgium
Actively Recruiting
16
Ziekenhuis Netwerk Antwerpen
Antwerp, Belgium
Actively Recruiting
17
UZ Leuven
Leuven, Belgium
Actively Recruiting
18
CHU-UCL Namur
Namur, Belgium
Actively Recruiting
19
QEII Health Sciences Centre
Halifax, Nova Scotia, Canada, B3H 3A7
Actively Recruiting
20
Juravinski Cancer Centre
Hamilton, Ontario, Canada, L8V 5C2
Actively Recruiting
21
Ottowa Hospital Research Institute
Ottawa, Canada, K1Y 4E9
Actively Recruiting
22
Saint John Regional Hospital
Saint John, Canada, E2L 4L2
Actively Recruiting
23
University Health Network Princess Margaret Cancer Centre
Toronto, Canada, M5G 2M9
Actively Recruiting
24
Vancouver Cancer Centre
Vancouver, Canada, V5Z 4E6
Actively Recruiting
25
CancerCare Manitoba
Winnipeg, Canada, R3E 0V9
Actively Recruiting
26
Aarhus University Hospitak Skjeby
Aarhus, Denmark
Actively Recruiting
27
Rigshospitalet
Copenhagen, Denmark
Actively Recruiting
28
St James's Hospital
Dublin, Ireland
Actively Recruiting
29
University Hospital Galway
Galway, Ireland
Actively Recruiting
30
Amsterdam UMC - location VUMC
Amsterdam, Netherlands, 1081 HV
Actively Recruiting
31
Reinier de Graafweg 3-11 - Postbus 5011 - 2625 AD Delft
Delft, Netherlands
Actively Recruiting
32
Universitair Medisch Centrum Groningen
Groningen, Netherlands
Actively Recruiting
33
Radboud University Medical Center Nijmegen
Nijmegen, Netherlands
Actively Recruiting
34
NL 331 - Haaglanden Medisch Centrum (HMC) - Haaglanden MC
The Hague, Netherlands
Actively Recruiting
35
Auckland City Hospital
Auckland, New Zealand, 1023
Actively Recruiting
36
Instituto Portugues de Oncologia de Lisboa Francisco Gentil
Lisbon, Portugal
Actively Recruiting
37
Narodny Onkologicky Ustav
Bratislava, Slovakia
Actively Recruiting
38
Hospital Del Mar
Barcelona, Spain, ES 08003
Actively Recruiting
39
Institut Catala d'Oncologia
Barcelona, Spain, ES 08908
Actively Recruiting
40
Complejo Hospitalario de Navarra
Pamplona, Spain
Actively Recruiting
41
University Hospital of Wales, Cardiff & Vale University Local Health Board
Cardiff, Cardiff, United Kingdom, CF14 4XW
Actively Recruiting
42
Blackpool Victoria Hospital
Blackpool, Lancashire, United Kingdom, FY3 8NR
Actively Recruiting
43
Freeman Hospital, Newcastle
Newcastle upon Tyne, Newcastle, United Kingdom, NE7 7DN
Actively Recruiting
44
Nottingham University Hospitals NHST
Nottingham, Nottingham, United Kingdom, NG51PB
Actively Recruiting
45
Lanarkshire
Glasgow, Scotland, United Kingdom, G71 8BB
Actively Recruiting
46
St George's Hospital
London, Tooting, United Kingdom, SW17 0QT
Actively Recruiting
47
Aberdeen Royal Infirmary
Aberdeen, United Kingdom, AB25 2ZN
Actively Recruiting
48
University Hospitals Birmingham
Birmingham, United Kingdom, B15 2GW
Actively Recruiting
49
Glan Clwyd Hospital
Bodelwyddan, United Kingdom, LL18 5UJ
Actively Recruiting
50
Bristol Haematology and Oncology Centre
Bristol, United Kingdom
Actively Recruiting
51
Colchester Hospital, ESNEFT
Colchester, United Kingdom, CO4 5JL
Actively Recruiting
52
University Hospital Coventry
Coventry, United Kingdom, CV2 2DX
Actively Recruiting
53
Beatson West of Scotland Cancer Centre
Glasgow, United Kingdom, G12 0YN
Actively Recruiting
54
Castle Hill Hospital
Hull, United Kingdom, HU16 5JQ
Actively Recruiting
55
St James University Hospital
Leeds, United Kingdom, LS9 7TF
Actively Recruiting
56
University Hospitals of Leicester NHS Trust
Leicester, United Kingdom, LE1 5WW
Actively Recruiting
57
The Clatterbridge Cancer Centre NHSFT, 65 Pembroke Place
Liverpool, United Kingdom, L7 8YA
Actively Recruiting
58
St Bartholomew's Hospital
London, United Kingdom, EC1A 7BE
Actively Recruiting
59
University College London Hospitals NHS Foundation Trust (UCLH)
London, United Kingdom, NW1 2BU
Actively Recruiting
60
Royal Marsden Hospital Chelsea
London, United Kingdom, SW3 6JZ
Actively Recruiting
61
Christie Hospital
Manchester, United Kingdom, M20 4BX
Actively Recruiting
62
Norfolk & Norwich University Hospital
Norwich, United Kingdom, NR4 7UY
Actively Recruiting
63
Churchill Hospital
Oxford, United Kingdom, OX3 7LE
Actively Recruiting
64
Derriford Hospital
Plymouth, United Kingdom, PL6 8DH
Actively Recruiting
65
Royal Hallamshire Hospital
Sheffield, United Kingdom, S10 2JF
Actively Recruiting
66
Southampton General Hospital
Southampton, United Kingdom, SO16 6YD
Actively Recruiting
67
Sunderland Royal Hospital
Sunderland, United Kingdom, SR4 7TP
Actively Recruiting
68
Royal Marsden Hospital
Sutton, United Kingdom, SM2 5PT
Actively Recruiting
69
Torbay Hospital
Torquay, United Kingdom, TQ2 7AA
Actively Recruiting
70
Royal Cornwall Hospital
Truro, United Kingdom, TR1 3LJ
Actively Recruiting
Research Team
R
RADAR Trial Coordinator
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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